Nicotine- N ′-Oxidation by Flavin Monooxygenase Enzymes

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 28; no. 2; pp. 311 - 320
• Main Authors: Perez-Paramo, Yadira X., Chen, Gang, Ashmore, Joseph H., Watson, Christy J. W., Nasrin, Shamema, Adams-Haduch, Jennifer, Wang, Renwei, Gao, Yu-Tang, Koh, Woon-Puay, Yuan, Jian-Min, Lazarus, Philip
• Format: Journal Article
• Language: English
• Published: United States 01.02.2019
• Subjects: Cotinine - analogs & derivatives; Cotinine - metabolism; Cotinine - urine; Cyclic N-Oxides - metabolism; Cyclic N-Oxides - urine; Cytochrome P-450 CYP2A6 - metabolism; HEK293 Cells; Humans; Inactivation, Metabolic; Nicotine - analogs & derivatives; Nicotine - metabolism; Nicotine - urine; Oxidation-Reduction; Oxygenases - genetics; Oxygenases - metabolism; Polymorphism, Genetic

The major mode of metabolism of nicotine is by hydroxylation via cytochrome P450 (CYP) 2A6, but it can also undergo glucuronidation by UDP-glucuronosyltransferases and oxidation by flavin monooxygenases (FMO). The goal of this study was to examine the potential importance of FMOs in nicotine metabol...