Pulmonary Vascular Distensibility and Early Pulmonary Vascular Remodeling in Pulmonary Hypertension

• Published in: Chest Vol. 156; no. 4; pp. 724 - 732
• Main Authors: Singh, Inderjit, Oliveira, Rudolf K.F., Naeije, Robert, Rahaghi, Farbod N., Oldham, William M., Systrom, David M., Waxman, Aaron B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2019
• Subjects: Adult; Aged; Aged, 80 and over; exercise capacity; Exercise Tolerance; Female; heart failure; Heart Failure - complications; Heart Failure - physiopathology; Humans; Hypertension, Pulmonary - complications; Hypertension, Pulmonary - physiopathology; Male; pulmonary arterial hypertension; Pulmonary Artery - pathology; Pulmonary Artery - physiopathology; pulmonary vascular distensibility; Retrospective Studies; RV-PA coupling; Stroke Volume; Vascular Remodeling; Ventricular Dysfunction, Right - complications; Ventricular Dysfunction, Right - physiopathology; mPAP; RV; PV; HR; HFpEF; RHC; PVR; AUC; TPR; ePH; pulmonary arterial hypertension; WU; heart failure; iCPET; RV-PA coupling; SV; CO; HFpEF+PVR; PAWP; PA; RV-PA; Ees; PAC; pulmonary vascular distensibility; PAH; exercise capacity; PH; Vo2; Ea

Exercise stress testing of the pulmonary circulation may uncover decreased pulmonary vascular (PV) distensibility as a cause of impaired aerobic exercise capacity and right ventricular (RV)-pulmonary arterial (PA) uncoupling. As such, it may help in the differential diagnosis of unexplained dyspnea,...