CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation

• Published in: The Journal of experimental medicine Vol. 198; no. 12; pp. 1829 - 1839
• Main Authors: Shibuya, Kazuko, Shirakawa, Jun, Kameyama, Tomie, Honda, Shin-Ichiro, Tahara-Hanaoka, Satoko, Miyamoto, Akitomo, Onodera, Masafumi, Sumida, Takayuki, Nakauchi, Hiromitsu, Miyoshi, Hiroyuki, Shibuya, Akira
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 15.12.2003
• Subjects: Antigens, Differentiation, T-Lymphocyte - physiology; CD226 antigen; CD4 antigen; CD8 antigen; Cell Differentiation; Cell Division; Gene Transfer, Horizontal; Genetic Vectors; Humans; Interleukin-12 - physiology; Interleukin-2 - pharmacology; Lentivirus - genetics; LFA-1 antigen; lipid rafts; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1 - physiology; Membrane Microdomains - physiology; T-Lymphocytes - physiology; Th1 Cells - physiology

Upon antigen recognition by the T cell receptor, lymphocyte function-associated antigen 1 (LFA-1) physically associates with the leukocyte adhesion molecule CD226 (DNAM-1) and the protein tyrosine kinase Fyn. We show that lentiviral vector-mediated mutant (Y-F322) CD226 transferred into naive CD4+ h...