Increased levels of plasma tissue factor pathway inhibitor in patients with glioblastoma and intracerebral metastases

• Published in: Neurological research (New York) Vol. 25; no. 4; p. 335
• Main Authors: Gerlach, Rüdiger, Scheuer, Timm, Böhm, Martina, Beck, Jürgen, Woszczyk, Alina, Raabe, Andreas, Scharrer, Inge, Seifert, Volker
• Format: Journal Article
• Language: English
• Published: England 01.06.2003
• Subjects: Adult; Aged; Astrocytoma - blood; Astrocytoma - secondary; Brain Neoplasms - blood; Brain Neoplasms - pathology; Female; Glioblastoma - blood; Glioblastoma - secondary; Hemangioblastoma - blood; Hemangioblastoma - secondary; Humans; Lipoproteins - blood; Male; Meningeal Neoplasms - blood; Meningeal Neoplasms - secondary; Meningioma - blood; Meningioma - secondary; Middle Aged; Neurilemmoma - blood; Neurilemmoma - secondary; Oligodendroglioma - blood; Oligodendroglioma - secondary; Pituitary Neoplasms - blood; Pituitary Neoplasms - secondary

Tissue Factor Pathway Inhibitor (TFPI) prevents further participation of Tissue Factor (TF) in the coagulation process by forming a stable quaternary complex of TF-FVIIa-FXa-TFPI. Recently, plasma TFPI level were found to be elevated in patients with malignant disease outside the brain. Therefore th...