Interleukin-13 and -4 expression in the central airways of smokers with chronic bronchitis

• Published in: The European respiratory journal Vol. 22; no. 4; pp. 602 - 608
• Main Authors: Miotto, D, Ruggieri, M.P, Boschetto, P, Cavallesco, G, Papi, A, Bononi, I, Piola, C, Murer, B, Fabbri, L.M, Mapp, C.E
• Format: Journal Article
• Language: English
• Published: Leeds Eur Respiratory Soc 01.10.2003; Maney
• Subjects: Adult; Aged; Aged, 80 and over; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; Bronchi - metabolism; Bronchi - pathology; Bronchitis, Chronic - metabolism; Chronic obstructive pulmonary disease, asthma; Female; Humans; Interferon-gamma - metabolism; Interleukins - metabolism; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Pneumology; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Smoking - metabolism; Lung; Asymptomatic; Mucus; Interleukin 4; Lung function; Surgery; Bronchus disease; Submucosa; Bronchitis; Th2 lymphocyte; cytokines; Chronic bronchitis; Human; Respiratory disease; Enzyme; Transferases; Cytokine; Double labelling; Malignant tumor; Symptomatology; mucus hypersecretion; Chronic; Treatment; Interferon; Inflammatory cell; Lesion; Aminomethyltransferase; Comparative study

The aim of this study was to determine whether the T‐helper 2‐type cytokines interleukin (IL)‐13 and ‐4 are involved in mucus hypersecretion, the hallmark of chronic bronchitis (CB). Surgical specimens were examined from 33 subjects undergoing lung resection for localised peripheral malignant pulmon...