Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription

• Published in: Molecular cancer therapeutics Vol. 20; no. 10; pp. 1880 - 1892
• Main Authors: Liu, Lixia, Deng, Yaotang, Zheng, Zhenming, Deng, Zihao, Zhang, Jinxin, Li, Jieyou, Liang, Manfeng, Zhou, Xueqiong, Tan, Wenchong, Yang, Hongjun, Neckers, Leonard M, Zou, Fei, Chen, Xuemei
• Format: Journal Article
• Language: English
• Published: United States 01.10.2021
• Subjects: Animals; Apoptosis; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Proliferation; DNA Damage; DNA Repair; DNA-Activated Protein Kinase - chemistry; Gene Expression Regulation, Neoplastic - drug effects; HSP90 Heat-Shock Proteins - antagonists & inhibitors; Humans; Hyperthermia, Induced - adverse effects; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prognosis; Protein Stability; RNA, Messenger - genetics; Survival Rate; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

As a conserved molecular chaperone, heat shock protein 90 (Hsp90) maintains the stability and homeostasis of oncoproteins and helps cancer cells survive. DNA-dependent protein kinase catalytic subunit (DNA-PKcs) plays a pivotal role in the non-homologous end joining pathway for DNA double-strand bre...