Chronic treatment with the serotonin 2A/2C receptor antagonist SR 46349B enhances the retention and efficiency of rule-guided behavior in mice

• Published in: Neurobiology of learning and memory Vol. 103; pp. 50 - 63
• Main Authors: Dougherty, John P., Oristaglio, Jeff
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.07.2013; Elsevier; Elsevier BV
• Subjects: Animal behavior; Animals; Behavior, Animal - drug effects; Behavioral psychophysiology; Biological and medical sciences; Chronic illnesses; Drug therapy; Fluorobenzenes - pharmacology; Fundamental and applied biological sciences. Psychology; Learning; Male; Maze Learning - drug effects; Memory; Memory - drug effects; Mice; Mouse; Neurons; Phenols - pharmacology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Receptor, Serotonin, 5-HT2A - physiology; Receptor, Serotonin, 5-HT2C - physiology; Reversal learning; Reversal Learning - drug effects; Rodents; Serotonin; Serotonin 2A receptor; Serotonin 5-HT2 Receptor Antagonists - pharmacology; SR 46349B; Learning; Serotonin 2A receptor; SR 46349B; Mouse; Reversal learning; Memory; 5-HT2A serotonin receptor; Rodentia; Vertebrata; Chronic; Mammalia; Treatment; Efficiency; Animal; Antagonist; Behavior; Rule

•Mice were trained to locate a food reward in one arm of a T-maze.•Chronic treatment with SR 46349B enhanced the retention of learned behavior.•SR 46349B also decreased response latencies and behavioral variability.•Chronic DOI treatment had no significant effects on task performance.•5-HT2A recepto...