Temozolomide Sensitizes MGMT-Deficient Tumor Cells to ATR Inhibitors

• Published in: Cancer research (Chicago, Ill.) Vol. 79; no. 17; pp. 4331 - 4338
• Main Authors: Jackson, Christopher B., Noorbakhsh, Seth I., Sundaram, Ranjini K., Kalathil, Aravind N., Ganesa, Sachita, Jia, Lanqi, Breslin, Hank, Burgenske, Danielle M., Gilad, Oren, Sarkaria, Jann N., Bindra, Ranjit S.
• Format: Journal Article
• Language: English
• Published: United States 01.09.2019

O -methylguanine-DNA methyltransferase (MGMT) is an enzyme that removes alkyl groups at the O -position of guanine in DNA. MGMT expression is reduced or absent in many tumor types derived from a diverse range of tissues, most notably in glioma. Low MGMT expression confers significant sensitivity to...