Neat1 regulates oxidized low-density lipoprotein-induced inflammation and lipid uptake in macrophages via paraspeckle formation

• Published in: Molecular medicine reports Vol. 17; no. 2; pp. 3092 - 3098
• Main Authors: Huang-Fu, Ning, Cheng, Jing-Song, Wang, Yong, Li, Zhen-Wei, Wang, Sheng-Huang
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.02.2018; D.A. Spandidos
• Subjects: Arteriosclerosis; Atherosclerosis; Biotechnology; Cancer; CD36 antigen; Gene expression; Glutamine; Immunoprecipitation; Inflammation; Isoforms; Lipids; Macrophages; Non-coding RNA; Phosphorylation; Polymerase chain reaction; Proline; Proteins; Reverse transcription; Scavenger receptors; Splicing factors; Western blotting; Grand Island New York; United States > US; China; Japan

Oxidized low-density lipoprotein (oxLDL) indu-ces macrophage inflammation and lipid uptake, and serves important roles in the development of atherosclerosis. The long non-coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (neat1) has two isoforms; the longer isoform, neat1_2, mediates the...