Update on Persistent Excessive Daytime Sleepiness in OSA

• Published in: Chest Vol. 158; no. 2; pp. 776 - 786
• Main Authors: Javaheri, Sogol, Javaheri, Shahrokh
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2020
• Subjects: excessive daytime sleepiness; OSA; pitolisant; solriamfetol; QTcF; TECSA; AHI; FDA; ESS; TONES3; excessive daytime sleepiness; MWT; solriamfetol; pitolisant; TEAE; EDS; Tmax; RLS; CYP; REM; OSA; PAP

OSA is a highly prevalent sleep disorder, and subjective excessive daytime sleepiness (EDS) is the cardinal symptom for which many individuals seek medical advice. Positive airway pressure (PAP) devices, first-line treatment for OSA, eliminates EDS in most patients. However, a subset of patients suf...