Stimulant-like action of nicotine on striatal dopamine transporter in the brain of adults with attention deficit hyperactivity disorder
Eleven adult patients with attention deficit hyperactivity disorder (ADHD) without medication, consuming 7–40 cigarettes per day, showed statistically significant lower values for striatal dopamine transporter (DAT) measured by [99mTc]TRODAT-1 SPECT compared to 11 non-smoking drug-naive patients wit...
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| Published in | The international journal of neuropsychopharmacology Vol. 5; no. 2; pp. 111 - 113 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge, UK
Cambridge University Press
01.06.2002
Oxford University Press |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Eleven adult patients with attention deficit hyperactivity disorder (ADHD) without medication, consuming 7–40 cigarettes per day, showed statistically significant lower values for striatal dopamine transporter (DAT) measured by [99mTc]TRODAT-1 SPECT compared to 11 non-smoking drug-naive patients with ADHD, matched for sex and age, despite higher ADHD scores for the smokers. Because stimulants have been shown to reduce primarily elevated DAT density in adults with ADHD, it can be suggested that nicotine acts in a similar way on striatal DAT as do stimulants. |
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| AbstractList | Eleven adult patients with attention deficit hyperactivity disorder (ADHD) without medication, consuming 7-40 cigarettes per day, showed statistically significant lower values for striatal dopamine transporter (DAT) measured by [99mTc]TRODAT-1 SPECT compared to 11 non-smoking drug-naive patients with ADHD, matched for sex and age, despite higher ADHD scores for the smokers. Because stimulants have been shown to reduce primarily elevated DAT density in adults with ADHD, it can be suggested that nicotine acts in a similar way on striatal DAT as do stimulants. Eleven adult patients with attention deficit hyperactivity disorder (ADHD) without medication, consuming 7-40 cigarettes per day, showed statistically significant lower values for striatal dopamine transporter (DAT) measured by [99mTc]TRODAT-1 SPECT compared to 11 non-smoking drug-naive patients with ADHD, matched for sex and age, despite higher ADHD scores for the smokers. Because stimulants have been shown to reduce primarily elevated DAT density in adults with ADHD, it can be suggested that nicotine acts in a similar way on striatal DAT as do stimulants. [PUBLICATION ABSTRACT] |
| Author | Kung, Hank F. Ackenheil, Manfred Dresel, Stefan H. Krause, Johanna Krause, Klaus-Henning Tatsch, Klaus |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12135534$$D View this record in MEDLINE/PubMed |
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| Keywords | nicotine Attention deficit hyperactivity disorder (ADHD) dopamine transporter single photon emission computed tomography (SPECT) TRODAT-1 |
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| Snippet | Eleven adult patients with attention deficit hyperactivity disorder (ADHD) without medication, consuming 7–40 cigarettes per day, showed statistically... Eleven adult patients with attention deficit hyperactivity disorder (ADHD) without medication, consuming 7-40 cigarettes per day, showed statistically... |
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| SubjectTerms | Adolescent Adult Attention Deficit Disorder with Hyperactivity - metabolism Attention Deficit Disorder with Hyperactivity - psychology Dopamine Plasma Membrane Transport Proteins Female Ganglionic Stimulants - pharmacology Humans Male Membrane Glycoproteins Membrane Transport Proteins - metabolism Middle Aged Neostriatum - drug effects Neostriatum - metabolism Nerve Tissue Proteins Nicotine - pharmacology Psychiatric Status Rating Scales RAPID COMMUNICATION Smoking - metabolism Stimulation, Chemical Tomography, Emission-Computed, Single-Photon |
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| Title | Stimulant-like action of nicotine on striatal dopamine transporter in the brain of adults with attention deficit hyperactivity disorder |
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