Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis

• Published in: The Journal of experimental medicine Vol. 179; no. 3; pp. 973 - 984
• Main Authors: Zhang, J, Markovic-Plese, S, Lacet, B, Raus, J, Weiner, H L, Hafler, D A
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.03.1994; The Rockefeller University Press
• Subjects: Adult; Antigens, CD - blood; Antigens, CD - cerebrospinal fluid; Biological and medical sciences; Cell Line; Female; Flow Cytometry; HLA-DQ Antigens - blood; HLA-DQ Antigens - cerebrospinal fluid; HLA-DR Antigens - blood; HLA-DR Antigens - cerebrospinal fluid; Humans; Interleukin-2 - pharmacology; Male; Medical sciences; Middle Aged; Multiple Sclerosis - blood; Multiple Sclerosis - cerebrospinal fluid; Multiple Sclerosis - immunology; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Myelin Basic Protein - immunology; Myelin Proteins - immunology; Myelin Proteolipid Protein; Nervous System Diseases - blood; Nervous System Diseases - cerebrospinal fluid; Nervous System Diseases - immunology; Neurology; Recombinant Proteins - pharmacology; T-Lymphocyte Subsets - immunology; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Human; Nervous system diseases; Multiple sclerosis; Myelin; Pathogenesis; Cytokine; Activation; Lipoprotein; Cerebrospinal fluid; Blood; Inflammatory disease; Specificity; Interleukin 2; Basic protein; Central nervous system disease; T-Lymphocyte; Proteolipid

Equal numbers of CD4+ T cells recognizing myelin basic protein (MBP) and proteolipid protein (PLP) are found in the circulation of normal individuals and multiple sclerosis (MS) patients. We hypothesized that if myelin-reactive T cells are critical for the pathogenesis of MS, they would exist in a d...