A Retrospective Analysis of the Clinical Effects of Neoadjuvant Combination Therapy with Full-Dose Gemcitabine and Radiation Therapy in Patients with Biliary Tract Cancer

• Published in: European journal of surgical oncology Vol. 43; no. 4; pp. 763 - 771
• Main Authors: Kobayashi, Shogo, MD, PhD, Tomokuni, Akira, MD, PhD, Gotoh, Kunihito, MD, PhD, Takahashi, Hidenori, MD, PhD, Akita, Hirofumi, MD, PhD, Marubashi, Shigeru, MD, PhD, Yamada, Terumasa, MD, PhD, Teshima, Teruki, MD, PhD, Fukui, Keisuke, PhD, Fujiwara, Yoshiyuki, MD, PhD, Sakon, Masato, MD, PhD
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2017
• Subjects: Aged; Antimetabolites, Antineoplastic - therapeutic use; Bile Duct Neoplasms - diagnostic imaging; Bile Duct Neoplasms - pathology; Bile Duct Neoplasms - therapy; Biliary tract cancer; Biliary Tract Neoplasms - diagnostic imaging; Biliary Tract Neoplasms - pathology; Biliary Tract Neoplasms - therapy; Chemoradiation; Chemoradiotherapy; Cholangiocarcinoma - diagnostic imaging; Cholangiocarcinoma - pathology; Cholangiocarcinoma - therapy; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Disease-Free Survival; Female; Gallbladder Neoplasms - diagnostic imaging; Gallbladder Neoplasms - pathology; Gallbladder Neoplasms - therapy; Hematology, Oncology and Palliative Medicine; Hepatectomy; Humans; Klatskin Tumor - diagnostic imaging; Klatskin Tumor - pathology; Klatskin Tumor - therapy; Male; Middle Aged; Neoadjuvant; Neoadjuvant Therapy; Neoplasm Staging; Pancreaticoduodenectomy; Retrospective Studies; Surgery; Survival; Survival Rate; Tomography, X-Ray Computed; neoadjuvant; carcinoembryonic antigen; inverse probability of treatment weighting; OS; Biliary tract cancer; survival; IPTW; CA19-9; portal vein embolization; BTC; carbohydrate antigen 19-9; UICC; overall survival; International Union Against Cancer; chemoradiation; CEA; PVE; RFS; recurrence free survival; Chemoradiation; Neoadjuvant; Survival

Abstract Purpose This study aims to evaluate survival and the objective response to neoadjuvant combination therapy with gemcitabine and radiation therapy in patients with biliary tract cancer. Methods The chemoradiation therapy regimen consisted of 3 cycles of full-dose gemcitabine (1000 mg/m2 at d...