Molecular responses of brain endothelial cells to radiation in a mouse model

• Published in: Journal of clinical neuroscience Vol. 19; no. 8; pp. 1154 - 1158
• Main Authors: Liu, Shinuo, Sammons, Vanessa, Fairhall, Jacob, Reddy, Raj, Tu, Jian, Hong Duong, T.T, Stoodley, Marcus
• Format: Journal Article
• Language: English
• Published: Scotland Elsevier Ltd 01.08.2012
• Subjects: Animals; Arteriovenous malformation; Brain - cytology; Cell Line, Transformed; Cell Survival; Dose-Response Relationship, Radiation; E-selectin; E-Selectin - metabolism; Endothelial Cells - radiation effects; Gene Expression Regulation - radiation effects; Mice; Models, Animal; Murine brain endothelial cell line; Neurology; Radiation; Radiosurgery; Radiosurgery - adverse effects; Thrombomodulin; Thrombomodulin - metabolism; Thromboplastin - metabolism; Time Factors; Tissue factor; E-selectin; Murine brain endothelial cell line; Thrombomodulin; Arteriovenous malformation; Radiosurgery; Tissue factor

Abstract Although most small arteriovenous malformations (AVM) are curable, over 90% of large lesions are untreatable with current surgery or radiosurgery. Endothelial cells (EC) are believed to be pivotal in the resulting vascular changes after AVM are irradiated, although their role is not fully u...