Sarcoma Cell Line Screen of Oncology Drugs and Investigational Agents Identifies Patterns Associated with Gene and microRNA Expression

• Published in: Molecular cancer therapeutics Vol. 14; no. 11; pp. 2452 - 2462
• Main Authors: Teicher, Beverly A, Polley, Eric, Kunkel, Mark, Evans, David, Silvers, Thomas, Delosh, Rene, Laudeman, Julie, Ogle, Chad, Reinhart, Russell, Selby, Michael, Connelly, John, Harris, Erik, Monks, Anne, Morris, Joel
• Format: Journal Article
• Language: English
• Published: United States 01.11.2015
• Subjects: Adult; Aurora Kinases - antagonists & inhibitors; Aurora Kinases - genetics; Cell Line, Tumor; Child; Cluster Analysis; Drug Screening Assays, Antitumor; Drugs, Investigational - pharmacology; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic - drug effects; Humans; MAP Kinase Kinase Kinases - antagonists & inhibitors; MAP Kinase Kinase Kinases - genetics; MicroRNAs - genetics; Oligonucleotide Array Sequence Analysis; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology; Poly(ADP-ribose) Polymerases - genetics; Protein Kinase Inhibitors - pharmacology; Receptor, IGF Type 1 - antagonists & inhibitors; Receptor, IGF Type 1 - genetics; Sarcoma - drug therapy; Sarcoma - genetics; Sarcoma - pathology

The diversity in sarcoma phenotype and genotype make treatment of this family of diseases exceptionally challenging. Sixty-three human adult and pediatric sarcoma lines were screened with 100 FDA-approved oncology agents and 345 investigational agents. The investigational agents' library enable...