Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data

• Published in: Briefings in bioinformatics Vol. 21; no. 3; pp. 1058 - 1068
• Main Authors: Yang, Qingxia, Li, Bo, Tang, Jing, Cui, Xuejiao, Wang, Yunxia, Li, Xiaofeng, Hu, Jie, Chen, Yuzong, Xue, Weiwei, Lou, Yan, Qiu, Yunqing, Zhu, Feng
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 21.05.2020; Oxford Publishing Limited (England)
• Subjects: Bioinformatics; Datasets; Diagnostic systems; Etiology; Feature selection; Medical research; Mental disorders; Random sampling; Reproducibility; Schizophrenia; Signatures; Stability; Statistical sampling; Strategy; Transcription factors; transcriptomics; combined analysis; schizophrenia; feature selection strategy; consistent gene signature

Abstract The etiology of schizophrenia (SCZ) is regarded as one of the most fundamental puzzles in current medical research, and its diagnosis is limited by the lack of objective molecular criteria. Although plenty of studies were conducted, SCZ gene signatures identified by these independent studie...