Distinct cell death markers identified in critical care patient survivors diagnosed with sepsis

• Published in: Immunology letters Vol. 231; pp. 1 - 10
• Main Authors: Mallarpu, Chandra Shekar, Ponnana, Meenakshi, Prasad, Sudhir, Singarapu, Maneendra, Kim, Jean, Haririparsa, Neda, Bratic, Nemanja, Brar, Harvinder, Chelluri, Lakshmi Kiran, Madiraju, Charitha
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2021
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; caspase-1; caspase-3; Caspases; Cell death; Cell Death - genetics; Cell Death - immunology; Critical Care; Critical Illness; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunophenotyping; Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Male; Middle Aged; MLKL, p62/SQSTM1; Sepsis; Sepsis - diagnosis; Sepsis - etiology; Sepsis - metabolism; Sepsis - therapy; Survivors; Sepsis; MLKL, p62/SQSTM1; Cell death; caspase-1; caspase-3

•Decrease in serum caspase-1 and p62 in sepsis survivor patients compared to healthy controls.•Decrease in serum caspase-1 and MLKL compared to caspase-3 in sepsis survivor patients.•Basal levels of serum caspase-3, caspase-1, MLKL and p62 are not different in healthy controls.•Altered expression of...