Impacts of the MHC class I-like XNC10 and innate-like T cells on tumor tolerance and rejection in the amphibian Xenopus

• Published in: Carcinogenesis (New York) Vol. 40; no. 7; pp. 924 - 935
• Main Authors: Banach, Maureen, Edholm, Eva-Stina, Gonzalez, Xavier, Benraiss, Abdellatif, Robert, Jacques
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 20.07.2019
• Subjects: Animals; Animals, Genetically Modified; Basale medisinske, odontologiske og veterinærmedisinske fag: 710; Basic medical, dental and veterinary science disciplines: 710; Cell Line, Tumor - transplantation; Disease Models, Animal; Gene Knockout Techniques; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class I - immunology; Histocompatibility Antigens Class I - metabolism; Humans; Inflammation, Microenvironment and Prevention; Larva; Medical disciplines: 700; Medisinske Fag: 700; Natural Killer T-Cells - immunology; Natural Killer T-Cells - metabolism; Receptors, Antigen, T-Cell, alpha-beta - immunology; Receptors, Antigen, T-Cell, alpha-beta - metabolism; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Thymus Neoplasms - immunology; Thymus Neoplasms - pathology; Tumor Escape - immunology; VDP; Xenopus laevis; Xenopus Proteins - immunology; Xenopus Proteins - metabolism

The conditions that lead to antitumor or protumor functions of natural killer T (NKT) cells against mammalian tumors are only partially understood. Therefore, insights into the evolutionary conservation of NKT and their analogs-innate-like T (iT) cells-may reveal factors that contribute to tumor era...