Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity - Robison, Timothy W.; Heflich, Robert H.; Manjanatha, Mugimane G.; Elespuru, Rosalie; Atrakchi, Aisar; Mei, Nan; Ding, Wei (Mutation research. Genetic toxicology and environmental mutagenesis, 2021)
Keywords: Comet assay; In vivo mutagenesis; Micronucleus assay; Pig-a mutation assay; Transgenic rodent mutation assay; HESI; In vivo mutagenesis; Micronucleus assay; IWGT; API; TGR mutation assay; Transgenic rodent mutation assay; Pig-a mutation assay; Comet assay