Mutations in the Measles Virus C Protein That Up Regulate Viral RNA Synthesis

• Published in: Virology (New York, N.Y.) Vol. 285; no. 1; pp. 100 - 109
• Main Authors: Reutter, Greta L., Cortese-Grogan, Case, Wilson, Julie, Moyer, Sue A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.06.2001
• Subjects: AC protein; C protein; Carrier Proteins - genetics; Cell Line; Chloramphenicol O-Acetyltransferase - metabolism; CMC protein; EdC protein; Measles Vaccine; Measles virus; Measles virus - chemistry; Measles virus - genetics; Measles virus - metabolism; Mutation; Nucleocapsid Proteins - genetics; Phosphoproteins - genetics; Recombination, Genetic; RNA, Viral - biosynthesis; Subacute Sclerosing Panencephalitis - virology; Transcription, Genetic; Up-Regulation

The measles virus RNA-dependent RNA polymerase consists of two virus-encoded subunits, the phosphoprotein (P) and the large (L) protein. The P mRNA also codes for a C protein in the +1 reading frame relative to P. The activities of the measles P and C proteins from the vaccine strain, EdB, a wild-ty...