Decrease in scale invariance of activity fluctuations with aging and in patients with suprasellar tumors

• Published in: Chronobiology international Vol. 35; no. 3; pp. 368 - 377
• Main Authors: Joustra, S. D., Gu, C., Rohling, J. H. T., Pickering, L., Klose, M., Hu, K., Scheer, F. A., Feldt-Rasmussen, U., Jennum, P. J., Pereira, A. M., Biermasz, N. R., Meijer, J. H.
• Format: Journal Article
• Language: English
• Published: England 04.03.2018
• Subjects: Actigraphy; Adenoma - physiopathology; Adult; Age Factors; Aged; Aging; Case-Control Studies; Circadian Rhythm; Craniopharyngioma - physiopathology; Exercise; Female; Humans; Male; Middle Aged; Monitoring, Ambulatory - methods; Pituitary Neoplasms - physiopathology; Suprachiasmatic Nucleus - physiopathology; Young Adult; Circadian rhythmicity; suprachiasmatic nucleus; nonfunctioning pituitary macroadenoma; scale invariance; craniopharyngioma; detrended fluctuation analysis

Motor activity in healthy young humans displays intrinsic fluctuations that are scale-invariant over a wide range of time scales (from minutes to hours). Human postmortem and animal lesion studies showed that the intact function of the suprachiasmatic nucleus (SCN) is required to maintain such scale...