Basic science of cardiac contractility modulation therapy: Molecular and electrophysiological mechanisms

• Published in: Heart rhythm Vol. 21; no. 1; pp. 82 - 88
• Main Authors: Masarone, Daniele, Kittleson, Michelle M., D’Onofrio, Antonio, Falco, Luigi, Fumarulo, Isabella, Massetti, Massimo, Crea, Filippo, Aspromonte, Nadia, Pacileo, Giuseppe
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2024
• Subjects: Calcium; Calcium handling; Cardiac contractility modulation therapy; Cardiotonic Agents; Fibrosis; Heart Failure - drug therapy; Heart failure with preserved ejection fraction; Heart failure with reduced ejection fraction; Humans; Molecular mechanism; Myocardial Contraction - physiology; Stroke Volume - physiology; Ventricular Dysfunction, Left; Heart failure with preserved ejection fraction; Ryr2; CRT; Cardiac contractility modulation therapy; Molecular mechanism; PLB; Heart failure with reduced ejection fraction; HFpEF; SERCA; HFrEF; FAO; CCMT; Calcium handling; ATP; HF; SR

In heart failure with reduced ejection fraction and heart failure with preserved ejection fraction, profound cellular and molecular changes have recently been documented in the failing myocardium. These changes include altered calcium handling and metabolic efficiency of the cardiac myocyte, reactiv...