Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion

• Published in: Cancer research (Chicago, Ill.) Vol. 80; no. 1; pp. 69 - 78
• Main Authors: Chen, Joseph, Ananthanarayanan, Badriprasad, Springer, Kelsey S, Wolf, Kayla J, Sheyman, Sharon M, Tran, Vivien D, Kumar, Sanjay
• Format: Journal Article
• Language: English
• Published: United States 01.01.2020

The aggressive brain tumor glioblastoma (GBM) is characterized by rapid cellular infiltration of brain tissue, raising the possibility that disease progression could potentially be slowed by disrupting the machinery of cell migration. The LIM kinase isoforms LIMK1 and LIMK2 (LIMK1/2) play important...