Interactions between gut microbiota and non-alcoholic liver disease: The role of microbiota-derived metabolites

• Published in: Pharmacological research Vol. 141; pp. 521 - 529
• Main Authors: Ding, Yufang, Yanagi, Karin, Cheng, Clint, Alaniz, Robert C., Lee, Kyongbum, Jayaraman, Arul
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2019
• Subjects: Amino Acids - immunology; Amino Acids - metabolism; Animals; Bacteria - immunology; Bacteria - metabolism; Bile acids; Bile Acids and Salts - immunology; Bile Acids and Salts - metabolism; Dysbiosis - complications; Dysbiosis - immunology; Dysbiosis - metabolism; Fatty Acids, Volatile - immunology; Fatty Acids, Volatile - metabolism; Gastrointestinal Microbiome; Humans; Indole; Inflammation; Inflammation - etiology; Inflammation - immunology; Inflammation - metabolism; Microbiota metabolites; NAFLD; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - immunology; Non-alcoholic Fatty Liver Disease - metabolism; Short chain fatty acids; FXR; NAFLD; Microbiota metabolites; Tributyrin (PubMed CID: 6050); TUDCA; Indole; HFD; UDCA; Indole (PubMed CID: 798); Short chain fatty acids; LPS; Taurine (PubMed CID: 1123); Butyrate (PubMed CID: 104775); Indole-3-acetic acid (PubMed CID: 802); Cholic acid (PubMed CID: 221493); Tryptophan (PubMed CID: 6305); Propionate (PubMed CID: 104745); DCA; GLP-1; Bile acids; Acetate (PubMed CID: 175); MCA; Inflammation; NASH; Tryptamine (PubMed CID: 1150); SCFAs

[Display omitted] There is increasing evidence that the intestinal microbiota plays a mechanistic role in the etiology of non-alcoholic fatty liver disease (NAFLD). Animal and human studies have linked small molecule metabolites produced by commensal bacteria in the gut contribute to not only intest...