A T-cell enhancer cooperates with NF-kappa B to yield cytokine induction of E-selectin gene transcription in endothelial cells

• Published in: The Journal of biological chemistry Vol. 267; no. 31; pp. 22385 - 22391
• Main Authors: Hooft van Huijsduijnen, R, Whelan, J, Pescini, R, Becker-André, M, Schenk, A M, DeLamarter, J F
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 05.11.1992
• Subjects: Base Sequence; Cell Adhesion Molecules - genetics; Cells, Cultured; Cytokines - pharmacology; DNA-Binding Proteins - metabolism; E-Selectin; Endothelium, Vascular - physiology; Enhancer Elements, Genetic; Gene Expression Regulation - drug effects; In Vitro Techniques; Molecular Sequence Data; NF-kappa B - physiology; Oligodeoxyribonucleotides - chemistry; Promoter Regions, Genetic; RNA, Messenger - genetics; T-Lymphocytes - physiology; Transcription, Genetic - drug effects

ELAM1 (endothelial leukocyte adhesion molecule 1, also known as E-selectin) is a highly tissue-specific adhesion molecule that is transiently and exclusively expressed on cytokine-induced endothelial cells. We have identified two proximal ELAM1 promoter elements and their DNA-binding factors that ar...