Long-Term Follow-up Assessment After the Arterial Switch Operation for Correction of Dextro-Transposition of the Great Arteries by Means of Exercise Myocardial Perfusion-Gated SPECT

• Published in: Pediatric cardiology Vol. 35; no. 2; pp. 197 - 207
• Main Authors: Pizzi, María N., Franquet, Elisa, Aguadé-Bruix, Santiago, Manso, Begoña, Casaldáliga, Jaume, Cuberas-Borrós, Gemma, Romero-Farina, Guillermo, Pinar, Josep, Castell-Conesa, Joan, García-Dorado, David, Candell-Riera, Jaume
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2014; Springer
• Subjects: Adolescent; Arteries; Cardiac patients; Cardiac Surgery; Cardiac Surgical Procedures; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography - methods; Cardiology; Child; Child, Preschool; Coronary Circulation - physiology; CT imaging; Exercise Test - methods; Female; Follow-Up Studies; Heart beat; Humans; Ischemia; Male; Medicine; Medicine & Public Health; Myocardial Ischemia - diagnostic imaging; Myocardial Ischemia - etiology; Myocardial Ischemia - physiopathology; Original Article; Postoperative Complications; Postoperative Period; Radiopharmaceuticals; Reproducibility of Results; Rest; Retrospective Studies; SPECT imaging; Technetium Tc 99m Sestamibi; Time Factors; Transposition of great arteries; Transposition of Great Vessels - diagnostic imaging; Transposition of Great Vessels - physiopathology; Transposition of Great Vessels - surgery; Vascular Surgery; Young Adult; Spain; Exercise; D-Transposition of great arteries; Myocardial perfusion; Coronary artery disease; SPECT
• DOI: 10.1007/s00246-013-0759-4
• ISSN: 0172-0643

The arterial switch operation (ASO) is the preferred technique for correcting transposition of the great arteries, but translocation and reimplantation of the coronary arteries can produce myocardial ischemia. This report aims to describe the authors’ experience with exercise single-photon emission computed tomography (SPECT) used to evaluate myocardial perfusion. Exercise-rest gated-myocardial perfusion SPECT was performed for 69 patients (49 boys; median age, 9 years; 5th percentile [6.4 years] to 95th percentile [15.6 years]), 64 of whom were asymptomatic 9.98 ± 3.20 years after ASO. During exercise testing, the patients reached 9.85 ± 3.05 metabolic equivalents (METs) and a median heart rate of 160 beats per minute (bpm), 5th percentile (106 bpm) to 95th percentile (196 bpm). Whereas 61 patients (88.41 %) had normal myocardial perfusion, 2 patients (2.9 %) had reversible defects, and 6 patients (8.7 %) had fixed defects. All the patients with perioperative ischemic complications (4/4, 100 %) had myocardial perfusion defects, whereas four patients (4/65, 6.15 %) without ischemic complications had abnormal perfusion ( p  = 0.0005). Age at the time of surgery did not differ significantly ( p  = 0.234) between the patients with perfusion defects and those with normal study results. No significant difference was observed between the patients who had an A coronary pattern (left coronary artery originating from the left sinus and the right coronary artery originating from the right sinus, n  = 47) and those who had a non-A coronary pattern ( n  = 22) ( p  = 1). The high rate for normality of exercise myocardial perfusion in our study suggests that myocardial perfusion gated-SPECT should be reserved for patients who have experienced perioperative ischemic complications or those with symptoms, at least during the first 10 years after the surgery.