The deafferented nonhuman primate is not a reliable model of intractable pain

• Published in: Neurological research (New York) Vol. 25; no. 2; p. 127
• Main Authors: Pioli, Elsa Y, Gross, Christian E, Meissner, Wassilios, Bioulac, Bernard H, Bezard, Erwan
• Format: Journal Article
• Language: English
• Published: England 01.03.2003
• Subjects: Animals; Behavior, Animal; Chronic Disease; Denervation; Disease Models, Animal; Female; Macaca fascicularis; Pain, Intractable - physiopathology; Reproducibility of Results; Rhizotomy; Self Mutilation - physiopathology

Before extending the application of motor cortex stimulation it is important to investigate the intimate mechanisms by which it alleviates intractable pain and to consider possible side effects. Self-mutilation in animals following extensive neurectomy or posterior rhizotomy of a limb is thought to...