Decreased Serum Thrombospondin-1 Levels in Pancreatic Cancer Patients Up to 24 Months Prior to Clinical Diagnosis: Association with Diabetes Mellitus

• Published in: Clinical cancer research Vol. 22; no. 7; pp. 1734 - 1743
• Main Authors: Jenkinson, Claire, Elliott, Victoria L., Evans, Anthony, Oldfield, Lucy, Jenkins, Rosalind E., O'Brien, Darragh P., Apostolidou, Sophia, Gentry-Maharaj, Aleksandra, Fourkala, Evangelia-O, Jacobs, Ian J., Menon, Usha, Cox, Trevor, Campbell, Fiona, Pereira, Stephen P., Tuveson, David A., Park, B. Kevin, Greenhalf, William, Sutton, Robert, Timms, John F., Neoptolemos, John P., Costello, Eithne
• Format: Journal Article
• Language: English
• Published: United States 01.04.2016
• Subjects: Aged; Animals; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal - blood; Carcinoma, Pancreatic Ductal - complications; Carcinoma, Pancreatic Ductal - diagnosis; Case-Control Studies; Diabetes Mellitus, Type 2 - complications; Disease Models, Animal; Early Detection of Cancer; Female; Humans; Male; Mice; Middle Aged; Neoplasm Staging; Pancreatic Neoplasms - blood; Pancreatic Neoplasms - complications; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - mortality; Patient Outcome Assessment; Platelet Count; Proteomics - methods; Reproducibility of Results; Thrombospondin 1 - blood; Time Factors

Purpose: Identification of serum biomarkers enabling earlier diagnosis of pancreatic ductal adenocarcinoma (PDAC) could improve outcome. Serum protein profiles in patients with preclinical disease and at diagnosis were investigated. Experimental Design: Serum from cases up to 4 years prior to PDAC d...