Strategies and safety simulations for ultrasonic cervical spinal cord neuromodulation

• Published in: Physics in medicine & biology Vol. 69; no. 12; pp. 125011 - 125029
• Main Authors: Xu, Rui, Bestmann, Sven, Treeby, Bradley E, Martin, Eleanor
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 21.06.2024
• Subjects: Cervical Cord - diagnostic imaging; focused ultrasound; Humans; Models, Biological; neuromodulation; Pressure; Safety; simulation; spinal cord; Spinal Cord Stimulation - instrumentation; Spinal Cord Stimulation - methods; spine; Ultrasonic Therapy - adverse effects; Ultrasonic Therapy - methods; neuromodulation; spine; spinal cord; simulation; focused ultrasound

Objective . Focused ultrasound spinal cord neuromodulation has been demonstrated in small animals. However, most of the tested neuromodulatory exposures are similar in intensity and exposure duration to the reported small animal threshold for possible spinal cord damage. All efforts must be made to...