Impaired myelopoiesis in congenital neutropenia: insights into clonal and malignant hematopoiesis

• Published in: Hematology Vol. 2021; no. 1; pp. 514 - 520
• Main Authors: Warren, Julia T, Link, Daniel C
• Format: Journal Article
• Language: English
• Published: United States American Society of Hematology 10.12.2021
• Subjects: Child, Preschool; Clonal Hematopoiesis; Congenital Bone Marrow Failure Syndromes - complications; Congenital Bone Marrow Failure Syndromes - physiopathology; Congenital Bone Marrow Failure Syndromes - therapy; Hematopoietic Stem Cell Transplantation; Humans; Infant; Leukemia, Myeloid, Acute - etiology; Leukemia, Myeloid, Acute - physiopathology; Leukemia, Myeloid, Acute - therapy; Middle Aged; Myelodysplastic Syndromes - etiology; Myelodysplastic Syndromes - physiopathology; Myelodysplastic Syndromes - therapy; Myelopoiesis; Neutropenia - complications; Neutropenia - congenital; Neutropenia - physiopathology; Neutropenia - therapy; Neutropenia: Doing More With Less; Shwachman-Diamond Syndrome - complications; Shwachman-Diamond Syndrome - physiopathology; Shwachman-Diamond Syndrome - therapy

A common feature of both congenital and acquired forms of bone marrow failure is an increased risk of developing acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Indeed, the development of MDS or AML is now the major cause of mortality in patients with congenital neutropenia. Thus, th...