IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype

• Published in: Cancer immunology research Vol. 7; no. 5; p. 759
• Main Authors: Alizadeh, Darya, Wong, Robyn A, Yang, Xin, Wang, Dongrui, Pecoraro, Joseph R, Kuo, Cheng-Fu, Aguilar, Brenda, Qi, Yue, Ann, David K, Starr, Renate, Urak, Ryan, Wang, Xiuli, Forman, Stephen J, Brown, Christine E
• Format: Journal Article
• Language: English
• Published: United States 01.05.2019
• Subjects: Animals; Cell Line, Tumor; Humans; Immunologic Memory; Immunotherapy, Adoptive; Interleukin-15 - immunology; Mechanistic Target of Rapamycin Complex 1 - immunology; Mice; Neoplasms - immunology; Neoplasms - therapy; Phenotype; Stem Cells - immunology; T-Lymphocytes - immunology; T-Lymphocytes - transplantation

Improvements in the quality and fitness of chimeric antigen receptor (CAR)-engineered T cells, through CAR design or manufacturing optimizations, could enhance the therapeutic potential of CAR-T cells. One parameter influencing the effectiveness of CAR-T cell therapy is the differentiation status of...