Evaluation of a transtympanic delivery system in Mus musculus for extended release steroids

• Published in: European journal of pharmaceutical sciences Vol. 126; pp. 3 - 10
• Main Authors: Dormer, Nathan H., Nelson-Brantley, Jennifer, Staecker, Hinrich, Berkland, Cory J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2019
• Subjects: Animals; Cellulose - analogs & derivatives; Cellulose - chemistry; Delayed-Action Preparations; Drug Carriers - chemistry; Drug Liberation; Fluorescent Dyes - chemistry; Humans; Injection, Intratympanic; Labyrinth Diseases - drug therapy; Membranes, Artificial; Mice, Inbred C57BL; Microspheres; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry; Round window membrane; Round Window, Ear - metabolism; Steroid; Steroids - administration & dosage; Steroids - adverse effects; Sudden hearing loss; Transtympanic; Steroid; Round window membrane; Microspheres; Sudden hearing loss; Transtympanic

The current investigation evaluated a novel extended release delivery system for treating inner ear diseases. The platform technology consists of a film forming agent (FFA) and microsphere component to localize and extend drug delivery within the ear. Studies evaluated dissolution kinetics of micros...