A Role for Dietary Selenium and Selenoproteins in Allergic Airway Inflammation

• Published in: Journal of Immunology Vol. 179; no. 5; pp. 3258 - 3267
• Main Authors: Hoffmann, Peter R, Jourdan-Le Saux, Claude, Hoffmann, Fukun W, Chang, Peter S, Bollt, Oana, He, Qingping, Tam, Elizabeth K, Berry, Marla J
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.09.2007
• Subjects: Animals; Asthma - immunology; Asthma - pathology; Asthma - prevention & control; CD4-Positive T-Lymphocytes - immunology; Cytokines - metabolism; Diet; Female; Glutathione Peroxidase - analysis; Glutathione Peroxidase - genetics; Glutathione Peroxidase - metabolism; Immunoglobulin E - blood; Inflammation - immunology; Interleukin-2 Receptor alpha Subunit - analysis; Lung - immunology; Lung - pathology; Mice; Mice, Inbred C57BL; Ovalbumin - immunology; Phosphorylation; RNA, Messenger - analysis; RNA, Messenger - metabolism; Selenium - administration & dosage; Selenoprotein P - genetics; Selenoprotein P - metabolism; STAT6 Transcription Factor - metabolism; Th2 Cells - immunology

Asthma is driven by allergic airway inflammation and involves increased levels of oxidative stress. This has led to speculation that antioxidants like selenium (Se) may play important roles in preventing or treating asthma. We fed diets containing low (0.08 parts per million), medium (0.25 parts per...