Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome - Yang, Bicheng; Huang, Yanrui; Zhang, Haifeng; Huang, Yan; Zhou, Huanjiao Jenny; Young, Lawrence; Xiao, Haipeng; Min, Wang (Journal of molecular and cellular cardiology, 2020)
Keywords: Animals; Bradycardia; Bradycardia - complications; Bradycardia - metabolism; Bradycardia - pathology; Cardiomyopathy, Dilated - complications; Cardiomyopathy, Dilated - metabolism; Cardiomyopathy, Dilated - pathology; Enhancer Elements, Genetic - genetics; HCN4; HDAC4; Histone Deacetylases - metabolism; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism; MEF2 Transcription Factors - metabolism; Mice, Knockout; Mitochondria, Heart - metabolism; Models, Biological; Oxidative Stress - genetics; Phenotype; Protein Binding; Reactive Oxygen Species - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sick sinus syndrome; Sick Sinus Syndrome - complications; Sick Sinus Syndrome - genetics; Sick Sinus Syndrome - pathology; Sinoatrial Node - metabolism; Sinoatrial Node - pathology; Thioredoxin 2; Thioredoxins - metabolism; HCN4; HDAC4; Bradycardia; Thioredoxin 2; Sick sinus syndrome