The Efficacy of Faecal Microbiota Transplant and Rectal Bacteriotherapy in Patients with Recurrent Clostridioides difficile Infection: A Retrospective Cohort Study

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 20; p. 3272
• Main Authors: Svensson, Camilla Kara, Cold, Frederik, Ribberholt, Iben, Zangenberg, Mike, Mirsepasi-Lauridsen, Hengameh Chloé, Petersen, Andreas Munk, Helms, Morten
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 18.10.2022; MDPI
• Subjects: Antibiotics; CDI; Clostridioides difficile; Clostridioides difficile infection; Clostridium Infections - therapy; Cohort analysis; Diarrhea; Drug dosages; Endoscopy; faecal microbiota transplantation; Fecal Microbiota Transplantation - adverse effects; FMT; Hospitals; Humans; Infectious diseases; Laboratories; Microbiota; Patients; RBT; rectal bacteriotherapy; Rectum; Recurrent infection; Regression analysis; Retrospective Studies; Transplantation; Transplants & implants; Treatment Outcome; Variance analysis; faecal microbiota transplantation; CDI; Clostridioides difficile infection; rectal bacteriotherapy; FMT; RBT

The most effective treatment for recurrent Clostridioides difficile infection (CDI) is faecal microbiota transplantation (FMT); however, the optimal route of administration is thus far unknown. This retrospective cohort study of 343 patients sought to evaluate the efficacy of treatment with FMT caps...