Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization

• Published in: Cancer research (Chicago, Ill.) Vol. 83; no. 8; pp. 1299 - 1314
• Main Authors: Karreman, Matthia A, Bauer, Alexander T, Solecki, Gergely, Berghoff, Anna S, Mayer, Chanté D, Frey, Katharina, Hebach, Nils, Feinauer, Manuel J, Schieber, Nicole L, Tehranian, Cedric, Mercier, Luc, Singhal, Mahak, Venkataramani, Varun, Schubert, Marc C, Hinze, Daniel, Hölzel, Michael, Helfrich, Iris, Schadendorf, Dirk, Schneider, Stefan W, Westphal, Dana, Augustin, Hellmut G, Goetz, Jacky G, Schwab, Yannick, Wick, Wolfgang, Winkler, Frank
• Format: Journal Article
• Language: English
• Published: United States 14.04.2023
• Subjects: Brain - pathology; Brain Neoplasms - pathology; Cell Line, Tumor; Endothelial Cells - metabolism; Endothelium, Vascular - pathology; Humans; Matrix Metalloproteinase 9 - metabolism

Crossing the blood-brain barrier is a crucial, rate-limiting step of brain metastasis. Understanding of the mechanisms of cancer cell extravasation from brain microcapillaries is limited as the underlying cellular and molecular processes cannot be adequately investigated using in vitro models and en...