The genotype C could play a key role in hepatitis B virus associated nephritis among the Northwest Chinese children

• Published in: European journal of internal medicine Vol. 24; no. 8; pp. 835 - 838
• Main Authors: Lei, Xiaoyan, Gao, Xia, Yang, Julan, Sun, Yonghong, Sai, Yipa, You, Wenping, Yuan, Hong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2013
• Subjects: Adolescent; Alanine Transaminase; Child; Child, Preschool; China; Complement C3 - immunology; DNA, Viral - genetics; Female; Genotype; Glomerulonephritis - complications; Glomerulonephritis - immunology; Glomerulonephritis - virology; hepatitis B virus; Hepatitis B virus - genetics; Hepatitis B, Chronic - complications; Hepatitis B, Chronic - immunology; Hepatitis B, Chronic - virology; Humans; Internal Medicine; Male; nephritis; Viral Load; China; nephritis; hepatitis B virus; genotype
• DOI: 10.1016/j.ejim.2013.07.009
• ISSN: 0953-6205

Abstract Background Hepatitis B virus-associated glomerulonephritis (HBV-GN) is a kind of immune complex-induced glomerulonephritis. The present study was designed to determine whether Hepatitis B virus (HBV) genotype is associated with glomerulonephritis in north-west Chinese children. Methods A total of 296 HBV-infected patients were enrolled in this study. The serum of patients was subjected to DNA extraction and the HBV genotypes were determined by PCR. Results The results showed that genotype C (49%) was predominant within the subjects, compared to HBV/B (38.5%), B/C recombinant (7.4%) and none B/C (5.1%). The serum tests showed that the changes of Complement 3 (C3) and alanine amino transferase (ALT) levels in the genotype C patients were significantly greater than those in the genotype B patients. The frequency of genotype C in HBV-GN patients was higher than that in non HBV-GN patients (χ2 value = 30.239, P < 0.001). But, it was not associated with renal dysfunction. Furthermore, The genotype C was associated with high HBV-DNA load (82.9% vs 17.1%, P < 0.001), which is seen more frequently in the HBV-GN children (86.3% vs 13.3%, P = 0.004). Conclusions The genotype C may play a role in HBV-GN children, via favoring HBV replication.