Activation of the Canonical β-Catenin Pathway by Histamine

• Published in: The Journal of biological chemistry Vol. 278; no. 52; pp. 52491 - 52496
• Main Authors: Diks, Sander H., Hardwick, James C., Diab, Remco M., van Santen, Marije M., Versteeg, Henri H., van Deventer, Sander J.H., Richel, Dick J., Peppelenbosch, Maikel P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.12.2003
• Subjects: Alkaline Phosphatase - metabolism; b-catenin; beta Catenin; Blotting, Western; Cell Line; Cell Line, Tumor; Cytoskeletal Proteins - metabolism; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; HeLa Cells; histamine; Histamine - metabolism; histamine receptor H1; Humans; In Vitro Techniques; Inflammation; Luciferases - metabolism; Macrophages - metabolism; Phosphorylation; Receptors, Histamine H1 - metabolism; Signal Transduction; Time Factors; Trans-Activators - metabolism; Transcription, Genetic; Transcriptional Activation; Up-Regulation

Histamine signaling is a principal regulator in a variety of pathophysiological processes including inflammation, gastric acid secretion, neurotransmission, and tumor growth. We report that histamine stimulation causes transactivation of a T cell factor/β-catenin-responsive construct in HeLa cells a...