Topical azithromycin and oral doxycycline therapy of meibomian gland dysfunction: a comparative clinical and spectroscopic pilot study

• Published in: Cornea Vol. 32; no. 1; p. 44
• Main Authors: Foulks, Gary N, Borchman, Douglas, Yappert, Marta, Kakar, Shelley
• Format: Journal Article
• Language: English
• Published: United States 01.01.2013
• Subjects: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - therapeutic use; Azithromycin - therapeutic use; Doxycycline - therapeutic use; Eyelid Diseases - drug therapy; Eyelid Diseases - metabolism; Female; Humans; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Meibomian Glands - drug effects; Meibomian Glands - metabolism; Middle Aged; Pilot Projects; Principal Component Analysis; Prospective Studies; Spectroscopy, Fourier Transform Infrared; Surveys and Questionnaires; Treatment Outcome
• ISSN: 1536-4798
• DOI: 10.1097/ICO.0b013e318254205f

Meibomian gland dysfunction (MGD) is a common clinical problem that is often associated with evaporative dry eye disease. Alterations of the lipids of the meibomian glands have been identified in several studies of MGD. This prospective, observational, open-label clinical trial documents the improve...