Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation

• Published in: The FASEB journal Vol. 33; no. 1; p. 1179
• Main Authors: Meng, Tie-Gang, Lu, Xukun, Guo, Lei, Hou, Guan-Mei, Ma, Xue-Shan, Li, Qian-Nan, Huang, Lin, Fan, Li-Hua, Zhao, Zheng-Hui, Ou, Xiang-Hong, OuYang, Ying-Chun, Schatten, Heide, Li, Lei, Wang, Zhen-Bo, Sun, Qing-Yuan
• Format: Journal Article
• Language: English
• Published: United States 01.01.2019
• Subjects: primed state; embryogenesis; naive state; 6-methyladenosine; gene expression
• ISSN: 1530-6860
• DOI: 10.1096/fj.201800719R

N6-methyladenosine (m A) is the most prevalent and reversible internal modification of mammalian messenger and noncoding RNAs mediated by specific m A writer, reader, and eraser proteins. As an m A writer, the methyltransferase-like 3-methyltransferase-like 14 (METTL14)-Wilms tumor 1-associated prot...