Bioequivalence revisited: influence of age and sex on CYP enzymes

• Published in: Clinical pharmacology and therapeutics Vol. 76; no. 6; p. 618
• Main Authors: Bebia, Zourab, Buch, Shama C, Wilson, John W, Frye, Reginald F, Romkes, Marjorie, Cecchetti, Alfred, Chaves-Gnecco, Diego, Branch, Robert A
• Format: Journal Article
• Language: English
• Published: United States 01.12.2004
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Aging - metabolism; Algorithms; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; Female; Genotype; Humans; Isoenzymes - genetics; Isoenzymes - metabolism; Male; Middle Aged; Models, Statistical; Phenotype; Sex Characteristics; Therapeutic Equivalency

The activity of cytochrome P450 (CYP) enzymes, which determine the rate of elimination of lipid-soluble drugs, demonstrates considerable interindividual variability. The extent to which age and sex influence CYP activity remains unclear in humans. Our objectives were to determine whether in vivo act...