Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial

• Published in: Anesthesiology (Philadelphia) Vol. 130; no. 6; pp. 958 - 970
• Main Authors: Klinger, Rebecca Y., Cooter, Mary, Bisanar, Tiffany, Terrando, Niccolò, Berger, Miles, Podgoreanu, Mihai V., Stafford-Smith, Mark, Newman, Mark F., Mathew, Joseph P., Blumenthal, James A., Karhausen, Jorn A., Kertai, Miklos D., Krishnamoorthy, Vijay, Li, Yi-Ju, Swaminathan, Madhav, Warner, David S., Funk, Bonita L., Brassard, Rachele, Toulgoat-Dubois, Yanne, Waweru, Peter, Babyak, Michael A., Browndyke, Jeffrey N., Welsh-Bohmer, Kathleen A., Sketch, Michael H., Bennett, Ellen R., Graffagnino, Carmelo, Laskowitz, Daniel T., Strittmatter, Warren J., Collins, Kevin, Smigla, Greg, Shearer, Ian, D’Amico, Thomas A., Daneshmand, Mani A., Gaca, Jeffrey G., Glower, Donald D., Haney, Jack, Harpole, David, Hartwig, Mathew G., Hughes, G. Chad, Klapper, Jacob A., Lin, Shu S., Lodge, Andrew J., Milano, Carmelo A., Plichta, Ryan P., Schroeder, Jacob N., Smith, Peter K., Tong, Betty C.
• Format: Journal Article
• Language: English
• Published: United States Copyright by , the American Society of Anesthesiologists, Inc. Wolters Kluwer Health, Inc 01.06.2019
• Subjects: Administration, Intravenous; Aged; Anesthetics, Local - administration & dosage; Anesthetics, Local - adverse effects; Cardiac Surgical Procedures - adverse effects; Cardiac Surgical Procedures - trends; Double-Blind Method; Female; Follow-Up Studies; Humans; Lidocaine - administration & dosage; Lidocaine - adverse effects; Male; Mental Status and Dementia Tests; Middle Aged; Neurocognitive Disorders - chemically induced; Neurocognitive Disorders - diagnosis; Neurocognitive Disorders - etiology; Postoperative Cognitive Complications - chemically induced; Postoperative Cognitive Complications - diagnosis; Postoperative Cognitive Complications - etiology; Prospective Studies; Treatment Outcome

WHAT WE ALREADY KNOW ABOUT THIS TOPICPreclinical and clinical studies suggest that lidocaine might be neuroprotective, which could benefit surgical patients at risk of neurologic compromise WHAT THIS ARTICLE TELLS US THAT IS NEWThis multicenter trial of intravenous lidocaine administered during and...