Asymmetric Bioreduction of a Bulky Ketone: 1-Phenyl-1-(2-phenylthiazol-5-yl)-methanone

• Published in: Advanced synthesis & catalysis Vol. 343; no. 6-7; pp. 738 - 743
• Main Authors: Roy, Sébastien, Alexandre, Vanessa, Neuwels, Michel, Le Texier, Laurence
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.08.2001; WILEY‐VCH Verlag
• Subjects: Asymmetry; biocatalysis; bioreduction; Catalysis; enantioselectivity; fermentation; Ketones; Microorganisms; Saccharomyces; Screening; Strain; Synthesis; yeast strains

We have investigated the preparation of (R)‐ and (S)‐1‐phenyl‐1‐(2‐phenylthiazol‐5‐yl)‐methanol by asymmetric bioreduction of the corresponding bulky ketone 1‐phenyl‐1‐(2‐phenylthiazol‐5‐yl)‐methanone with whole microbial cells. A short screening of 38 microbial strains allowed the selection of two...