Common anesthetic used in preclinical PET imaging inhibits metabolism of the PET tracer [18F]3F4AP

• Published in: Journal of neurochemistry Vol. 168; no. 9; pp. 2577 - 2586
• Main Authors: Ramos‐Torres, Karla, Sun, Yang, Takahashi, Kazue, Zhou, Yu‐Peng, Brugarolas, Pedro
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2024
• Subjects: [18F]3F4AP; Aminopyridines - pharmacokinetics; Aminopyridines - pharmacology; Anesthesia; Anesthetics, Inhalation - pharmacology; Animals; Brain; Brain - diagnostic imaging; Brain - drug effects; Brain - metabolism; Cytochrome P450; Cytochromes P450; Disulfiram; Disulfiram - pharmacology; Fluorine isotopes; Fluorine Radioisotopes; Image acquisition; Isoflurane; Isoflurane - pharmacology; Laboratory animals; Male; Medical imaging; Metabolism; Mice; Mice, Inbred C57BL; Neuroimaging; PET imaging; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Radioactive tracers; radiometabolites; Radiopharmaceuticals; radiotracer; metabolism; [18F]3F4AP; PET imaging; radiotracer; radiometabolites; anesthesia

Positron emission tomography (PET) imaging studies in laboratory animals are almost always performed under isoflurane anesthesia to ensure that the subject stays still during the image acquisition. Isoflurane is effective, safe, and easy to use, and it is generally assumed to not have an impact on t...