Common anesthetic used in preclinical PET imaging inhibits metabolism of the PET tracer [18F]3F4AP - Ramos‐Torres, Karla; Sun, Yang; Takahashi, Kazue; Zhou, Yu‐Peng; Brugarolas, Pedro (Journal of neurochemistry, 2024)
Keywords: [18F]3F4AP; Aminopyridines - pharmacokinetics; Aminopyridines - pharmacology; Anesthesia; Anesthetics, Inhalation - pharmacology; Animals; Brain; Brain - diagnostic imaging; Brain - drug effects; Brain - metabolism; Cytochrome P450; Cytochromes P450; Disulfiram; Disulfiram - pharmacology; Fluorine isotopes; Fluorine Radioisotopes; Image acquisition; Isoflurane; Isoflurane - pharmacology; Laboratory animals; Male; Medical imaging; Metabolism; Mice; Mice, Inbred C57BL; Neuroimaging; PET imaging; Positron emission; Positron emission tomography; Positron-Emission Tomography - methods; Radioactive tracers; radiometabolites; Radiopharmaceuticals; radiotracer; metabolism; [18F]3F4AP; PET imaging; radiotracer; radiometabolites; anesthesia