Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury

• Published in: Electrophoresis Vol. 33; no. 24; pp. 3693 - 3704
• Main Authors: Boutté, Angela M., Yao, Changping, Kobeissy, Firas, May Lu, Xi-Chun, Zhang, Zhiqun, Wang, Kevin K., Schmid, Kara, Tortella, Frank C., Dave, Jitendra R.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.12.2012
• Subjects: Animals; Biology; Biomarker; Biomarkers; Biomarkers - analysis; Biomarkers - chemistry; Brain; Brain Chemistry; Control equipment; Databases, Protein; Disease Models, Animal; Head Injuries, Penetrating - metabolism; Head Injuries, Penetrating - pathology; Histocytochemistry; Injuries; Kinases; Male; Penetrating ballistic-like brain injury; Proteins; Proteins - analysis; Proteome - analysis; Proteome - chemistry; Proteomics; Proteomics - methods; Rats; Rats, Sprague-Dawley; Systems biology; Systems Biology - methods; UCH-L1

Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D‐DIGE‐PMF‐MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic‐like brain injury (PBBI). Brain‐specific systems biology analysis...