Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury

Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D‐DIGE‐PMF‐MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic‐like brain injury (PBBI). Brain‐specific systems biology analysis...

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Published inElectrophoresis Vol. 33; no. 24; pp. 3693 - 3704
Main Authors Boutté, Angela M., Yao, Changping, Kobeissy, Firas, May Lu, Xi-Chun, Zhang, Zhiqun, Wang, Kevin K., Schmid, Kara, Tortella, Frank C., Dave, Jitendra R.
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 01.12.2012
Subjects
Animals
Biology
Biomarker
Biomarkers
Biomarkers - analysis
Biomarkers - chemistry
Brain
Brain Chemistry
Control equipment
Databases, Protein
Disease Models, Animal
Head Injuries, Penetrating - metabolism
Head Injuries, Penetrating - pathology
Histocytochemistry
Injuries
Kinases
Male
Penetrating ballistic-like brain injury
Proteins
Proteins - analysis
Proteome - analysis
Proteome - chemistry
Proteomics
Proteomics - methods
Rats
Rats, Sprague-Dawley
Systems biology
Systems Biology - methods
UCH-L1
Online AccessGet full text

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Abstract Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D‐DIGE‐PMF‐MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic‐like brain injury (PBBI). Brain‐specific systems biology analysis of brain tissue identified 386 proteins having a fold change of more than 2, of which 321 proteins were increased and 65 were decreased 24 h after PBBI compared to sham controls. The majority of upregulated proteins were cytoskeletal (10.5%), nucleic acid binding (9.3%), or kinases (8.9%). Most proteins were involved in protein metabolism (22.7%), signal transduction (20.4%), and development (9.6%). Pathway analysis indicated that these proteins were involved in neurite outgrowth and cell differentiation. Semiquantitative Western blotting of 6, 24, 48, and 72 h after PBBI indicated ubiquitin carboxyl‐terminal hydrolase isozyme L1 (a proposed traumatic brain injury biomarker in human clinical trials), tyrosine hydroxylase, and syntaxin‐6 were found to be consistently elevated in brain tissue and cerebral spinal fluid after PBBI compared to sham controls. Combining proteomics and brain‐specific systems biology can define underlying mechanisms of traumatic brain injury and provide valuable information in biomarker discovery that, in turn, may lead to novel therapeutic targets.
AbstractList Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2 D -DIGE- PMF - MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic-like brain injury (PBBI). Brain-specific systems biology analysis of brain tissue identified 386 proteins having a fold change of more than 2, of which 321 proteins were increased and 65 were decreased 24 h after PBBI compared to sham controls. The majority of upregulated proteins were cytoskeletal (10.5%), nucleic acid binding (9.3%), or kinases (8.9%). Most proteins were involved in protein metabolism (22.7%), signal transduction (20.4%), and development (9.6%). Pathway analysis indicated that these proteins were involved in neurite outgrowth and cell differentiation. Semiquantitative W estern blotting of 6, 24, 48, and 72 h after PBBI indicated ubiquitin carboxyl-terminal hydrolase isozyme L 1 (a proposed traumatic brain injury biomarker in human clinical trials), tyrosine hydroxylase, and syntaxin-6 were found to be consistently elevated in brain tissue and cerebral spinal fluid after PBBI compared to sham controls. Combining proteomics and brain-specific systems biology can define underlying mechanisms of traumatic brain injury and provide valuable information in biomarker discovery that, in turn, may lead to novel therapeutic targets.
Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D‐DIGE‐PMF‐MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic‐like brain injury (PBBI). Brain‐specific systems biology analysis of brain tissue identified 386 proteins having a fold change of more than 2, of which 321 proteins were increased and 65 were decreased 24 h after PBBI compared to sham controls. The majority of upregulated proteins were cytoskeletal (10.5%), nucleic acid binding (9.3%), or kinases (8.9%). Most proteins were involved in protein metabolism (22.7%), signal transduction (20.4%), and development (9.6%). Pathway analysis indicated that these proteins were involved in neurite outgrowth and cell differentiation. Semiquantitative Western blotting of 6, 24, 48, and 72 h after PBBI indicated ubiquitin carboxyl‐terminal hydrolase isozyme L1 (a proposed traumatic brain injury biomarker in human clinical trials), tyrosine hydroxylase, and syntaxin‐6 were found to be consistently elevated in brain tissue and cerebral spinal fluid after PBBI compared to sham controls. Combining proteomics and brain‐specific systems biology can define underlying mechanisms of traumatic brain injury and provide valuable information in biomarker discovery that, in turn, may lead to novel therapeutic targets.
Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2 D ‐DIGE‐ PMF ‐ MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic‐like brain injury (PBBI). Brain‐specific systems biology analysis of brain tissue identified 386 proteins having a fold change of more than 2, of which 321 proteins were increased and 65 were decreased 24 h after PBBI compared to sham controls. The majority of upregulated proteins were cytoskeletal (10.5%), nucleic acid binding (9.3%), or kinases (8.9%). Most proteins were involved in protein metabolism (22.7%), signal transduction (20.4%), and development (9.6%). Pathway analysis indicated that these proteins were involved in neurite outgrowth and cell differentiation. Semiquantitative W estern blotting of 6, 24, 48, and 72 h after PBBI indicated ubiquitin carboxyl‐terminal hydrolase isozyme L 1 (a proposed traumatic brain injury biomarker in human clinical trials), tyrosine hydroxylase, and syntaxin‐6 were found to be consistently elevated in brain tissue and cerebral spinal fluid after PBBI compared to sham controls. Combining proteomics and brain‐specific systems biology can define underlying mechanisms of traumatic brain injury and provide valuable information in biomarker discovery that, in turn, may lead to novel therapeutic targets.
Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D-DIGE-PMF-MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic-like brain injury (PBBI). Brain-specific systems biology analysis of brain tissue identified 386 proteins having a fold change of more than 2, of which 321 proteins were increased and 65 were decreased 24 h after PBBI compared to sham controls. The majority of upregulated proteins were cytoskeletal (10.5%), nucleic acid binding (9.3%), or kinases (8.9%). Most proteins were involved in protein metabolism (22.7%), signal transduction (20.4%), and development (9.6%). Pathway analysis indicated that these proteins were involved in neurite outgrowth and cell differentiation. Semiquantitative Western blotting of 6, 24, 48, and 72 h after PBBI indicated ubiquitin carboxyl-terminal hydrolase isozyme L1 (a proposed traumatic brain injury biomarker in human clinical trials), tyrosine hydroxylase, and syntaxin-6 were found to be consistently elevated in brain tissue and cerebral spinal fluid after PBBI compared to sham controls. Combining proteomics and brain-specific systems biology can define underlying mechanisms of traumatic brain injury and provide valuable information in biomarker discovery that, in turn, may lead to novel therapeutic targets.Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D-DIGE-PMF-MS as a preliminary screen to detect biomarkers in a rat model of penetrating ballistic-like brain injury (PBBI). Brain-specific systems biology analysis of brain tissue identified 386 proteins having a fold change of more than 2, of which 321 proteins were increased and 65 were decreased 24 h after PBBI compared to sham controls. The majority of upregulated proteins were cytoskeletal (10.5%), nucleic acid binding (9.3%), or kinases (8.9%). Most proteins were involved in protein metabolism (22.7%), signal transduction (20.4%), and development (9.6%). Pathway analysis indicated that these proteins were involved in neurite outgrowth and cell differentiation. Semiquantitative Western blotting of 6, 24, 48, and 72 h after PBBI indicated ubiquitin carboxyl-terminal hydrolase isozyme L1 (a proposed traumatic brain injury biomarker in human clinical trials), tyrosine hydroxylase, and syntaxin-6 were found to be consistently elevated in brain tissue and cerebral spinal fluid after PBBI compared to sham controls. Combining proteomics and brain-specific systems biology can define underlying mechanisms of traumatic brain injury and provide valuable information in biomarker discovery that, in turn, may lead to novel therapeutic targets.
Author Schmid, Kara
Yao, Changping
Tortella, Frank C.
May Lu, Xi-Chun
Kobeissy, Firas
Wang, Kevin K.
Boutté, Angela M.
Zhang, Zhiqun
Dave, Jitendra R.
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Cites_doi 10.1097/CCM.0b013e318186a4a0
10.1186/1742-2094-6-19
10.1046/j.0305-1846.2001.00333.x
10.1006/exnr.1999.7152
10.1089/neu.2011.1916
10.1007/s002590000308
10.1089/neu.2008.0811
10.1186/gb-2011-12-4-220
10.1089/neu.2011.1989
10.3389/fneur.2011.00012
10.1111/j.1471-4159.2006.03719.x
10.1089/neu.2010.1653
10.1089/neu.2006.23.1828
10.1007/s00441-011-1196-4
10.1089/neu.2011.1872
10.1111/j.1445-2197.2010.05268.x
10.1111/j.1460-9568.2006.05275.x
10.1016/j.annemergmed.2011.08.021
10.3171/2010.5.JNS08914
10.1111/j.1460-9568.2010.07097.x
10.1016/j.expneurol.2010.05.001
10.1016/j.brainres.2006.11.087
10.1097/CCM.0b013e3181b788ab
10.1016/j.neulet.2008.03.061
10.5483/BMBRep.2002.35.1.067
10.1038/sj.jcbfm.9600073
10.1186/cc10286
10.1007/s12028-010-9342-5
10.1016/j.pbb.2009.07.006
10.1038/onc.2010.287
10.1089/neu.2008.0629
10.1089/neu.2008.0863
10.1212/WNL.0b013e3181fd62d2
10.1016/j.pmrj.2011.02.012
10.1089/neu.2011.2149
10.1186/1742-2094-4-17
10.1385/JMN:27:2:175
10.1111/j.1471-4159.2007.04844.x
10.1089/neu.2010.1278
10.1089/neu.2011.2127
10.1093/jnen/64.3.194
10.1089/neu.2010.1564
10.1089/neu.2006.23.1094
10.1016/j.neubiorev.2009.03.011
10.1089/neu.2011.1789
10.1016/j.neulet.2006.08.086
10.1089/neu.2005.22.313
10.1016/j.jneuroim.2012.01.001
10.1016/j.neuint.2007.05.007
10.1016/j.nbd.2011.09.018
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References Kobori, N., Clifton, G. L., Dash, P. K., J. Neurotrauma. 2006, 23, 1094-1102.
Blyth, B. J., Farahvar, A., He, H., Nayak, A., Yang, C., Shaw, G., Bazarian, J. J., J. Neurotrauma. 2011, 28, 2453-2462.
Papa, L., Akinyi, L., Liu, M. C., Pineda, J. A., Tepas, J. J., 3rd, Oli, M. W., Zheng, W., Robinson, G., Robicsek, S. A., Gabrielli, A., Heaton, S. C., Hannay, H. J., Demery, J. A., Brophy, G. M., Layon, J., Robertson, C. S., Hayes, R. L., Wang, K. K., Crit. Care Med. 2010, 38, 138-144.
Bales, J. W., Wagner, A. K., Kline, A. E., Dixon, C. E., Neurosci. Biobehav. Rev. 2009, 33, 981-1003.
Won, S. J., Kim, D. Y., Gwag, B. J., J. Biochem. Mol. Biol. 2002, 35, 67-86.
Torres, G. E., J. Neurochem. 2006, 97(Suppl 1), 3-10.
Stein, D. M., Lindell, A. L., Murdock, K. R., Kufera, J. A., Menaker, J., Bochicchio, G., Aarabi, B., Scalea, T. M., J. Neurotrauma. 2012, 29, 1140-1149.
Marcoux, J., McArthur, D. A., Miller, C., Glenn, T. C., Villablanca, P., Martin, N. A., Hovda, D. A., Alger, J. R., Vespa, P. M., Crit. Care Med. 2008, 36, 2871-2877.
Wu, A., Ying, Z., Gomez-Pinilla, F., J. Neurotrauma. 2011, 28, 2113-2122.
Mondello, S., Papa, L., Buki, A., Bullock, M. R., Czeiter, E., Tortella, F. C., Wang, K. K., Hayes, R. L., Crit. Care 2011, 15, R156.
Setsuie, R., Wada, K., Neurochem. Int. 2007, 51, 105-111.
Staropoli, J. F., Abeliovich, A., J. Mol. Neurosci. 2005, 27, 175-183.
Shear, D. A., Lu, X. C., Pedersen, R., Wei, G., Chen, Z., Davis, A., Yao, C., Dave, J., Tortella, F. C., J. Neurotrauma. 2011, 28, 2185-2195.
Mondello, S., Linnet, A., Buki, A., Robicsek, S., Gabrielli, A., Tepas, J., Papa, L., Brophy, G. M., Tortella, F., Hayes, R. L., Wang, K. K., Neurosurgery 2012, 70, 666-675.
Lakshmanan, R., Loo, J. A., Drake, T., Leblanc, J., Ytterberg, A. J., McArthur, D. L., Etchepare, M., Vespa, P. M., Neurocrit. Care 2010, 12, 324-336.
Chen, Z., Tortella, F. C., Dave, J. R., Marshall, V. S., Clarke, D. L., Sing, G., Du, F., Lu, X. C., J. Neurotrauma. 2009, 26, 1987-1997.
Williams, A. J., Hartings, J. A., Lu, X. C., Rolli, M. L., Tortella, F. C., J. Neurotrauma. 2006, 23, 1828-1846.
Vos, P. E., Jacobs, B., Andriessen, T. M., Lamers, K. J., Borm, G. F., Beems, T., Edwards, M., Rosmalen, C. F., Vissers, J. L., Neurology 2010, 75, 1786-1793.
Kwon, S. K., Kovesdi, E., Gyorgy, A. B., Wingo, D., Kamnaksh, A., Walker, J., Long, J. B., Agoston, D. V., Front Neurol. 2011, 2, 12.
von Bohlen und Halbach, O., Cell Tissue Res. 2011, 345, 1-19.
Williams, A. J., Ling, G. S., Tortella, F. C., Neurosci. Lett. 2006, 408, 183-188.
Johnson, V. E., Stewart, W., Smith, D. H., Exp. Neurol. 2012.
Donnemiller, E., Brenneis, C., Wissel, J., Scherfler, C., Poewe, W., Riccabona, G., Wenning, G. K., Eur. J. Nucl. Med. 2000, 27, 1410-1414.
Garcia-Bonilla, L., Cid, C., Alcazar, A., Burda, J., Ayuso, I., Salinas, M., J. Neurochem. 2007, 103, 1368-1380.
Kobeissy, F. H., Guingab-Cagmat, J. D., Razafsha, M., O'Steen, L., Zhang, Z., Hayes, R. L., Chiu, W. T., Wang, K. K., PM R 2011, 3, S139-147.
Papa, L., Lewis, L. M., Falk, J. L., Zhang, Z., Silvestri, S., Giordano, P., Brophy, G. M., Demery, J. A., Dixit, N. K., Ferguson, I., Liu, M. C., Mo, J., Akinyi, L., Schmid, K., Mondello, S., Robertson, C. S., Tortella, F. C., Hayes, R. L., Wang, K. K., Ann. Emerg. Med. 2011, 59, 471-483.
Mondello, S., Robicsek, S. A., Gabrielli, A., Brophy, G. M., Papa, L., Tepas, J., Robertson, C., Buki, A., Scharf, D., Jixiang, M., Akinyi, L., Muller, U., Wang, K. K., Hayes, R. L., J. Neurotrauma. 2010, 27, 1203-1213.
Williams, A. J., Hartings, J. A., Lu, X. C., Rolli, M. L., Dave, J. R., Tortella, F. C., J. Neurotrauma. 2005, 22, 313-331.
Williams, A. J., Wei, H. H., Dave, J. R., Tortella, F. C., J. Neuroinflammation 2007, 4, 17.
Todorov, I. T., Werness, B. A., Wang, H. Q., Buddharaju, L. N., Todorova, P. D., Slocum, H. K., Brooks, J. S., Huberman, J. A., Lab. Invest 1998, 78, 73-78.
Yao, C., Williams, A. J., Ottens, A. K., Lu, X. C., Liu, M. C., Hayes, R. L., Wang, K. K., Tortella, F. C., Dave, J. R., J. Neurotrauma. 2009, 26, 1295-1305.
Thom, M., Martinian, L., Williams, G., Stoeber, K., Sisodiya, S. M., J. Neuropathol. Exp. Neurol. 2005, 64, 194-201.
Crawford, F., Crynen, G., Reed, J., Mouzon, B., Bishop, A., Katz, B., Ferguson, S., Phillips, J., Ganapathi, V., Mathura, V., Roses, A., Mullan, M., J. Neurotrauma. 2012, 29, 246-260.
Sun, X., Zhang, Q. W., Xu, M., Guo, J. J., Shen, S. W., Wang, Y. Q., Sun, F. Y., Neurobiol. Dis. 2012, 45, 601-609.
Liberatore, G. T., Finkelstein, D. I., Wong, J. Y., Horne, M. K., Porritt, M. J., Donnan, G. A., Howells, D. W., Exp. Neurol. 1999, 159, 565-573.
Vespa, P., Bergsneider, M., Hattori, N., Wu, H. M., Huang, S. C., Martin, N. A., Glenn, T. C., McArthur, D. L., Hovda, D. A., J. Cereb. Blood Flow Metab. 2005, 25, 763-774.
Mills, J. D., Bailes, J. E., Sedney, C. L., Hutchins, H., Sears, B., J. Neurosurg. 2011, 114, 77-84.
Wharton, S. B., Chan, K. K., Anderson, J. R., Stoeber, K., Williams, G. H., Neuropathol. Appl. Neurobiol. 2001, 27, 305-313.
Berger, R. P., Hayes, R. L., Richichi, R., Beers, S. R., Wang, K. K., J. Neurotrauma. 2012, 29, 162-167.
Czeiter, E., Mondello, S., Kovacs, N., Sandor, J., Gabrielli, A., Schmid, K., Tortella, F., Wang, K. K., Hayes, R. L., Barzo, P., Ezer, E., Doczi, T., Buki, A., J. Neurotrauma. 2012, 29, 1770-1778.
Lu, X. C., Chen, R. W., Yao, C., Wei, H., Yang, X., Liao, Z., Dave, J. R., Tortella, F. C., J. Neurotrauma. 2009, 26, 141-154.
Yan, H. Q., Ma, X., Chen, X., Li, Y., Shao, L., Dixon, C. E., Brain Res. 2007, 1134, 171-179.
Shear, D. A., Williams, A. J., Sharrow, K., Lu, X. C., Tortella, F. C., Pharmacol. Biochem. Behav. 2009, 94, 56-62.
Monnerie, H., Tang-Schomer, M. D., Iwata, A., Smith, D. H., Kim, H. A., Le Roux, P. D., Exp. Neurol. 2010, 224, 415-423.
Brophy, G. M., Mondello, S., Papa, L., Robicsek, S. A., Gabrielli, A., Tepas, J., 3rd, Buki, A., Robertson, C., Tortella, F. C., Hayes, R. L., Wang, K. K., J. Neurotrauma. 2011, 28, 861-870.
Villoslada, P., Baranzini, S., J. Neuroimmunol. 2012, 248, 58-65.
Kabayama, H., Tokushige, N., Takeuchi, M., Mikoshiba, K., Neurosci. Lett. 2008, 436, 340-344.
Lau, K. M., Chan, Q. K., Pang, J. C., Li, K. K., Yeung, W. W., Chung, N. Y., Lui, P. C., Tam, Y. S., Li, H. M., Zhou, L., Wang, Y., Mao, Y., Ng, H. K., Oncogene 2010, 29, 5475-5489.
Cadosch, D., Thyer, M., Gautschi, O. P., Lochnit, G., Frey, S. P., Zellweger, R., Filgueira, L., Skirving, A. P., ANZ J. Surg. 2010, 80, 542-547.
Habgood, M. D., Bye, N., Dziegielewska, K. M., Ek, C. J., Lane, M. A., Potter, A., Morganti-Kossmann, C., Saunders, N. R., Eur. J. Neurosci. 2007, 25, 231-238.
Wei, H. H., Lu, X. C., Shear, D. A., Waghray, A., Yao, C., Tortella, F. C., Dave, J. R., J. Neuroinflammation 2009, 6, 19.
Sarikas, A., Hartmann, T., Pan, Z. Q., Genome Biol. 2011, 12, 220.
Liu, M. C., Akinyi, L., Scharf, D., Mo, J., Larner, S. F., Muller, U., Oli, M. W., Zheng, W., Kobeissy, F., Papa, L., Lu, X. C., Dave, J. R., Tortella, F. C., Hayes, R. L., Wang, K. K., Eur. J. Neurosci. 2010, 31, 722-732.
2007; 103
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2010; 31
2010; 75
2010; 38
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References_xml – reference: Brophy, G. M., Mondello, S., Papa, L., Robicsek, S. A., Gabrielli, A., Tepas, J., 3rd, Buki, A., Robertson, C., Tortella, F. C., Hayes, R. L., Wang, K. K., J. Neurotrauma. 2011, 28, 861-870.
– reference: Vespa, P., Bergsneider, M., Hattori, N., Wu, H. M., Huang, S. C., Martin, N. A., Glenn, T. C., McArthur, D. L., Hovda, D. A., J. Cereb. Blood Flow Metab. 2005, 25, 763-774.
– reference: Villoslada, P., Baranzini, S., J. Neuroimmunol. 2012, 248, 58-65.
– reference: Todorov, I. T., Werness, B. A., Wang, H. Q., Buddharaju, L. N., Todorova, P. D., Slocum, H. K., Brooks, J. S., Huberman, J. A., Lab. Invest 1998, 78, 73-78.
– reference: Blyth, B. J., Farahvar, A., He, H., Nayak, A., Yang, C., Shaw, G., Bazarian, J. J., J. Neurotrauma. 2011, 28, 2453-2462.
– reference: Wharton, S. B., Chan, K. K., Anderson, J. R., Stoeber, K., Williams, G. H., Neuropathol. Appl. Neurobiol. 2001, 27, 305-313.
– reference: Torres, G. E., J. Neurochem. 2006, 97(Suppl 1), 3-10.
– reference: Bales, J. W., Wagner, A. K., Kline, A. E., Dixon, C. E., Neurosci. Biobehav. Rev. 2009, 33, 981-1003.
– reference: Kwon, S. K., Kovesdi, E., Gyorgy, A. B., Wingo, D., Kamnaksh, A., Walker, J., Long, J. B., Agoston, D. V., Front Neurol. 2011, 2, 12.
– reference: Johnson, V. E., Stewart, W., Smith, D. H., Exp. Neurol. 2012.
– reference: Papa, L., Akinyi, L., Liu, M. C., Pineda, J. A., Tepas, J. J., 3rd, Oli, M. W., Zheng, W., Robinson, G., Robicsek, S. A., Gabrielli, A., Heaton, S. C., Hannay, H. J., Demery, J. A., Brophy, G. M., Layon, J., Robertson, C. S., Hayes, R. L., Wang, K. K., Crit. Care Med. 2010, 38, 138-144.
– reference: Stein, D. M., Lindell, A. L., Murdock, K. R., Kufera, J. A., Menaker, J., Bochicchio, G., Aarabi, B., Scalea, T. M., J. Neurotrauma. 2012, 29, 1140-1149.
– reference: Mondello, S., Robicsek, S. A., Gabrielli, A., Brophy, G. M., Papa, L., Tepas, J., Robertson, C., Buki, A., Scharf, D., Jixiang, M., Akinyi, L., Muller, U., Wang, K. K., Hayes, R. L., J. Neurotrauma. 2010, 27, 1203-1213.
– reference: Shear, D. A., Lu, X. C., Pedersen, R., Wei, G., Chen, Z., Davis, A., Yao, C., Dave, J., Tortella, F. C., J. Neurotrauma. 2011, 28, 2185-2195.
– reference: von Bohlen und Halbach, O., Cell Tissue Res. 2011, 345, 1-19.
– reference: Monnerie, H., Tang-Schomer, M. D., Iwata, A., Smith, D. H., Kim, H. A., Le Roux, P. D., Exp. Neurol. 2010, 224, 415-423.
– reference: Thom, M., Martinian, L., Williams, G., Stoeber, K., Sisodiya, S. M., J. Neuropathol. Exp. Neurol. 2005, 64, 194-201.
– reference: Liu, M. C., Akinyi, L., Scharf, D., Mo, J., Larner, S. F., Muller, U., Oli, M. W., Zheng, W., Kobeissy, F., Papa, L., Lu, X. C., Dave, J. R., Tortella, F. C., Hayes, R. L., Wang, K. K., Eur. J. Neurosci. 2010, 31, 722-732.
– reference: Williams, A. J., Ling, G. S., Tortella, F. C., Neurosci. Lett. 2006, 408, 183-188.
– reference: Williams, A. J., Wei, H. H., Dave, J. R., Tortella, F. C., J. Neuroinflammation 2007, 4, 17.
– reference: Czeiter, E., Mondello, S., Kovacs, N., Sandor, J., Gabrielli, A., Schmid, K., Tortella, F., Wang, K. K., Hayes, R. L., Barzo, P., Ezer, E., Doczi, T., Buki, A., J. Neurotrauma. 2012, 29, 1770-1778.
– reference: Sarikas, A., Hartmann, T., Pan, Z. Q., Genome Biol. 2011, 12, 220.
– reference: Cadosch, D., Thyer, M., Gautschi, O. P., Lochnit, G., Frey, S. P., Zellweger, R., Filgueira, L., Skirving, A. P., ANZ J. Surg. 2010, 80, 542-547.
– reference: Lau, K. M., Chan, Q. K., Pang, J. C., Li, K. K., Yeung, W. W., Chung, N. Y., Lui, P. C., Tam, Y. S., Li, H. M., Zhou, L., Wang, Y., Mao, Y., Ng, H. K., Oncogene 2010, 29, 5475-5489.
– reference: Mills, J. D., Bailes, J. E., Sedney, C. L., Hutchins, H., Sears, B., J. Neurosurg. 2011, 114, 77-84.
– reference: Shear, D. A., Williams, A. J., Sharrow, K., Lu, X. C., Tortella, F. C., Pharmacol. Biochem. Behav. 2009, 94, 56-62.
– reference: Sun, X., Zhang, Q. W., Xu, M., Guo, J. J., Shen, S. W., Wang, Y. Q., Sun, F. Y., Neurobiol. Dis. 2012, 45, 601-609.
– reference: Liberatore, G. T., Finkelstein, D. I., Wong, J. Y., Horne, M. K., Porritt, M. J., Donnan, G. A., Howells, D. W., Exp. Neurol. 1999, 159, 565-573.
– reference: Yan, H. Q., Ma, X., Chen, X., Li, Y., Shao, L., Dixon, C. E., Brain Res. 2007, 1134, 171-179.
– reference: Marcoux, J., McArthur, D. A., Miller, C., Glenn, T. C., Villablanca, P., Martin, N. A., Hovda, D. A., Alger, J. R., Vespa, P. M., Crit. Care Med. 2008, 36, 2871-2877.
– reference: Kobori, N., Clifton, G. L., Dash, P. K., J. Neurotrauma. 2006, 23, 1094-1102.
– reference: Habgood, M. D., Bye, N., Dziegielewska, K. M., Ek, C. J., Lane, M. A., Potter, A., Morganti-Kossmann, C., Saunders, N. R., Eur. J. Neurosci. 2007, 25, 231-238.
– reference: Mondello, S., Papa, L., Buki, A., Bullock, M. R., Czeiter, E., Tortella, F. C., Wang, K. K., Hayes, R. L., Crit. Care 2011, 15, R156.
– reference: Williams, A. J., Hartings, J. A., Lu, X. C., Rolli, M. L., Dave, J. R., Tortella, F. C., J. Neurotrauma. 2005, 22, 313-331.
– reference: Donnemiller, E., Brenneis, C., Wissel, J., Scherfler, C., Poewe, W., Riccabona, G., Wenning, G. K., Eur. J. Nucl. Med. 2000, 27, 1410-1414.
– reference: Wu, A., Ying, Z., Gomez-Pinilla, F., J. Neurotrauma. 2011, 28, 2113-2122.
– reference: Crawford, F., Crynen, G., Reed, J., Mouzon, B., Bishop, A., Katz, B., Ferguson, S., Phillips, J., Ganapathi, V., Mathura, V., Roses, A., Mullan, M., J. Neurotrauma. 2012, 29, 246-260.
– reference: Lu, X. C., Chen, R. W., Yao, C., Wei, H., Yang, X., Liao, Z., Dave, J. R., Tortella, F. C., J. Neurotrauma. 2009, 26, 141-154.
– reference: Papa, L., Lewis, L. M., Falk, J. L., Zhang, Z., Silvestri, S., Giordano, P., Brophy, G. M., Demery, J. A., Dixit, N. K., Ferguson, I., Liu, M. C., Mo, J., Akinyi, L., Schmid, K., Mondello, S., Robertson, C. S., Tortella, F. C., Hayes, R. L., Wang, K. K., Ann. Emerg. Med. 2011, 59, 471-483.
– reference: Berger, R. P., Hayes, R. L., Richichi, R., Beers, S. R., Wang, K. K., J. Neurotrauma. 2012, 29, 162-167.
– reference: Mondello, S., Linnet, A., Buki, A., Robicsek, S., Gabrielli, A., Tepas, J., Papa, L., Brophy, G. M., Tortella, F., Hayes, R. L., Wang, K. K., Neurosurgery 2012, 70, 666-675.
– reference: Wei, H. H., Lu, X. C., Shear, D. A., Waghray, A., Yao, C., Tortella, F. C., Dave, J. R., J. Neuroinflammation 2009, 6, 19.
– reference: Williams, A. J., Hartings, J. A., Lu, X. C., Rolli, M. L., Tortella, F. C., J. Neurotrauma. 2006, 23, 1828-1846.
– reference: Vos, P. E., Jacobs, B., Andriessen, T. M., Lamers, K. J., Borm, G. F., Beems, T., Edwards, M., Rosmalen, C. F., Vissers, J. L., Neurology 2010, 75, 1786-1793.
– reference: Setsuie, R., Wada, K., Neurochem. Int. 2007, 51, 105-111.
– reference: Staropoli, J. F., Abeliovich, A., J. Mol. Neurosci. 2005, 27, 175-183.
– reference: Kabayama, H., Tokushige, N., Takeuchi, M., Mikoshiba, K., Neurosci. Lett. 2008, 436, 340-344.
– reference: Chen, Z., Tortella, F. C., Dave, J. R., Marshall, V. S., Clarke, D. L., Sing, G., Du, F., Lu, X. C., J. Neurotrauma. 2009, 26, 1987-1997.
– reference: Lakshmanan, R., Loo, J. A., Drake, T., Leblanc, J., Ytterberg, A. J., McArthur, D. L., Etchepare, M., Vespa, P. M., Neurocrit. Care 2010, 12, 324-336.
– reference: Kobeissy, F. H., Guingab-Cagmat, J. D., Razafsha, M., O'Steen, L., Zhang, Z., Hayes, R. L., Chiu, W. T., Wang, K. K., PM R 2011, 3, S139-147.
– reference: Yao, C., Williams, A. J., Ottens, A. K., Lu, X. C., Liu, M. C., Hayes, R. L., Wang, K. K., Tortella, F. C., Dave, J. R., J. Neurotrauma. 2009, 26, 1295-1305.
– reference: Won, S. J., Kim, D. Y., Gwag, B. J., J. Biochem. Mol. Biol. 2002, 35, 67-86.
– reference: Garcia-Bonilla, L., Cid, C., Alcazar, A., Burda, J., Ayuso, I., Salinas, M., J. Neurochem. 2007, 103, 1368-1380.
– volume: 248
  start-page: 58
  year: 2012
  end-page: 65
  publication-title: J. Neuroimmunol.
– volume: 64
  start-page: 194
  year: 2005
  end-page: 201
  publication-title: J. Neuropathol. Exp. Neurol.
– volume: 224
  start-page: 415
  year: 2010
  end-page: 423
  publication-title: Exp. Neurol.
– volume: 80
  start-page: 542
  year: 2010
  end-page: 547
  publication-title: ANZ J. Surg.
– volume: 38
  start-page: 138
  year: 2010
  end-page: 144
  publication-title: Crit. Care Med.
– volume: 31
  start-page: 722
  year: 2010
  end-page: 732
  publication-title: Eur. J. Neurosci.
– volume: 97
  start-page: 3
  issue: Suppl 1
  year: 2006
  end-page: 10
  publication-title: J. Neurochem.
– volume: 26
  start-page: 141
  year: 2009
  end-page: 154
  publication-title: J. Neurotrauma.
– volume: 114
  start-page: 77
  year: 2011
  end-page: 84
  publication-title: J. Neurosurg.
– volume: 159
  start-page: 565
  year: 1999
  end-page: 573
  publication-title: Exp. Neurol.
– volume: 28
  start-page: 2113
  year: 2011
  end-page: 2122
  publication-title: J. Neurotrauma.
– volume: 75
  start-page: 1786
  year: 2010
  end-page: 1793
  publication-title: Neurology
– volume: 12
  start-page: 324
  year: 2010
  end-page: 336
  publication-title: Neurocrit. Care
– volume: 78
  start-page: 73
  year: 1998
  end-page: 78
  publication-title: Lab. Invest
– volume: 23
  start-page: 1828
  year: 2006
  end-page: 1846
  publication-title: J. Neurotrauma.
– volume: 45
  start-page: 601
  year: 2012
  end-page: 609
  publication-title: Neurobiol. Dis.
– volume: 15
  start-page: R156
  year: 2011
  publication-title: Crit. Care
– volume: 28
  start-page: 2453
  year: 2011
  end-page: 2462
  publication-title: J. Neurotrauma.
– volume: 25
  start-page: 763
  year: 2005
  end-page: 774
  publication-title: J. Cereb. Blood Flow Metab.
– volume: 436
  start-page: 340
  year: 2008
  end-page: 344
  publication-title: Neurosci. Lett.
– volume: 29
  start-page: 5475
  year: 2010
  end-page: 5489
  publication-title: Oncogene
– volume: 103
  start-page: 1368
  year: 2007
  end-page: 1380
  publication-title: J. Neurochem.
– volume: 408
  start-page: 183
  year: 2006
  end-page: 188
  publication-title: Neurosci. Lett.
– volume: 59
  start-page: 471
  year: 2011
  end-page: 483
  publication-title: Ann. Emerg. Med.
– volume: 1134
  start-page: 171
  year: 2007
  end-page: 179
  publication-title: Brain Res.
– volume: 4
  start-page: 17
  year: 2007
  publication-title: J. Neuroinflammation
– volume: 35
  start-page: 67
  year: 2002
  end-page: 86
  publication-title: J. Biochem. Mol. Biol.
– volume: 22
  start-page: 313
  year: 2005
  end-page: 331
  publication-title: J. Neurotrauma.
– volume: 27
  start-page: 1410
  year: 2000
  end-page: 1414
  publication-title: Eur. J. Nucl. Med.
– volume: 94
  start-page: 56
  year: 2009
  end-page: 62
  publication-title: Pharmacol. Biochem. Behav.
– volume: 6
  start-page: 19
  year: 2009
  publication-title: J. Neuroinflammation
– volume: 345
  start-page: 1
  year: 2011
  end-page: 19
  publication-title: Cell Tissue Res.
– volume: 23
  start-page: 1094
  year: 2006
  end-page: 1102
  publication-title: J. Neurotrauma.
– volume: 26
  start-page: 1295
  year: 2009
  end-page: 1305
  publication-title: J. Neurotrauma.
– volume: 29
  start-page: 1140
  year: 2012
  end-page: 1149
  publication-title: J. Neurotrauma.
– volume: 3
  start-page: S139
  year: 2011
  end-page: 147
  publication-title: PM R
– volume: 12
  start-page: 220
  year: 2011
  publication-title: Genome Biol.
– volume: 36
  start-page: 2871
  year: 2008
  end-page: 2877
  publication-title: Crit. Care Med.
– volume: 28
  start-page: 861
  year: 2011
  end-page: 870
  publication-title: J. Neurotrauma.
– volume: 51
  start-page: 105
  year: 2007
  end-page: 111
  publication-title: Neurochem. Int.
– volume: 29
  start-page: 1770
  year: 2012
  end-page: 1778
  publication-title: J. Neurotrauma.
– volume: 29
  start-page: 162
  year: 2012
  end-page: 167
  publication-title: J. Neurotrauma.
– volume: 27
  start-page: 175
  year: 2005
  end-page: 183
  publication-title: J. Mol. Neurosci.
– volume: 70
  start-page: 666
  year: 2012
  end-page: 675
  publication-title: Neurosurgery
– volume: 33
  start-page: 981
  year: 2009
  end-page: 1003
  publication-title: Neurosci. Biobehav. Rev.
– volume: 25
  start-page: 231
  year: 2007
  end-page: 238
  publication-title: Eur. J. Neurosci.
– volume: 29
  start-page: 246
  year: 2012
  end-page: 260
  publication-title: J. Neurotrauma.
– volume: 26
  start-page: 1987
  year: 2009
  end-page: 1997
  publication-title: J. Neurotrauma.
– year: 2012
  publication-title: Exp. Neurol.
– volume: 27
  start-page: 1203
  year: 2010
  end-page: 1213
  publication-title: J. Neurotrauma.
– volume: 2
  start-page: 12
  year: 2011
  publication-title: Front Neurol.
– volume: 27
  start-page: 305
  year: 2001
  end-page: 313
  publication-title: Neuropathol. Appl. Neurobiol.
– volume: 28
  start-page: 2185
  year: 2011
  end-page: 2195
  publication-title: J. Neurotrauma.
– ident: e_1_2_7_41_1
  doi: 10.1097/CCM.0b013e318186a4a0
– ident: e_1_2_7_16_1
  doi: 10.1186/1742-2094-6-19
– ident: e_1_2_7_31_1
  doi: 10.1046/j.0305-1846.2001.00333.x
– ident: e_1_2_7_25_1
  doi: 10.1006/exnr.1999.7152
– ident: e_1_2_7_17_1
  doi: 10.1089/neu.2011.1916
– ident: e_1_2_7_39_1
  doi: 10.1007/s002590000308
– ident: e_1_2_7_37_1
  doi: 10.1089/neu.2008.0811
– ident: e_1_2_7_48_1
  doi: 10.1186/gb-2011-12-4-220
– ident: e_1_2_7_46_1
  doi: 10.1089/neu.2011.1989
– ident: e_1_2_7_11_1
  doi: 10.3389/fneur.2011.00012
– ident: e_1_2_7_38_1
  doi: 10.1111/j.1471-4159.2006.03719.x
– ident: e_1_2_7_52_1
  doi: 10.1089/neu.2010.1653
– volume: 70
  start-page: 666
  year: 2012
  ident: e_1_2_7_47_1
  publication-title: Neurosurgery
– ident: e_1_2_7_26_1
  doi: 10.1089/neu.2006.23.1828
– ident: e_1_2_7_32_1
  doi: 10.1007/s00441-011-1196-4
– ident: e_1_2_7_43_1
  doi: 10.1089/neu.2011.1872
– ident: e_1_2_7_12_1
  doi: 10.1111/j.1445-2197.2010.05268.x
– ident: e_1_2_7_53_1
  doi: 10.1111/j.1460-9568.2006.05275.x
– ident: e_1_2_7_6_1
  doi: 10.1016/j.annemergmed.2011.08.021
– ident: e_1_2_7_44_1
  doi: 10.3171/2010.5.JNS08914
– ident: e_1_2_7_3_1
  doi: 10.1111/j.1460-9568.2010.07097.x
– ident: e_1_2_7_22_1
  doi: 10.1016/j.expneurol.2010.05.001
– ident: e_1_2_7_24_1
  doi: 10.1016/j.brainres.2006.11.087
– ident: e_1_2_7_4_1
  doi: 10.1097/CCM.0b013e3181b788ab
– ident: e_1_2_7_21_1
  doi: 10.1016/j.neulet.2008.03.061
– ident: e_1_2_7_8_1
  doi: 10.5483/BMBRep.2002.35.1.067
– ident: e_1_2_7_42_1
  doi: 10.1038/sj.jcbfm.9600073
– ident: e_1_2_7_51_1
  doi: 10.1186/cc10286
– ident: e_1_2_7_40_1
  doi: 10.1007/s12028-010-9342-5
– ident: e_1_2_7_19_1
  doi: 10.1016/j.pbb.2009.07.006
– ident: e_1_2_7_33_1
  doi: 10.1038/onc.2010.287
– ident: e_1_2_7_18_1
  doi: 10.1089/neu.2008.0629
– ident: e_1_2_7_28_1
  doi: 10.1089/neu.2008.0863
– ident: e_1_2_7_7_1
  doi: 10.1212/WNL.0b013e3181fd62d2
– ident: e_1_2_7_10_1
  doi: 10.1016/j.pmrj.2011.02.012
– ident: e_1_2_7_5_1
  doi: 10.1089/neu.2011.2149
– ident: e_1_2_7_15_1
  doi: 10.1186/1742-2094-4-17
– year: 2012
  ident: e_1_2_7_20_1
  publication-title: Exp. Neurol.
– ident: e_1_2_7_49_1
  doi: 10.1385/JMN:27:2:175
– ident: e_1_2_7_34_1
  doi: 10.1111/j.1471-4159.2007.04844.x
– ident: e_1_2_7_2_1
  doi: 10.1089/neu.2010.1278
– ident: e_1_2_7_54_1
  doi: 10.1089/neu.2011.2127
– ident: e_1_2_7_30_1
  doi: 10.1093/jnen/64.3.194
– volume: 78
  start-page: 73
  year: 1998
  ident: e_1_2_7_29_1
  publication-title: Lab. Invest
– ident: e_1_2_7_50_1
  doi: 10.1089/neu.2010.1564
– ident: e_1_2_7_23_1
  doi: 10.1089/neu.2006.23.1094
– ident: e_1_2_7_36_1
  doi: 10.1016/j.neubiorev.2009.03.011
– ident: e_1_2_7_9_1
  doi: 10.1089/neu.2011.1789
– ident: e_1_2_7_27_1
  doi: 10.1016/j.neulet.2006.08.086
– ident: e_1_2_7_14_1
  doi: 10.1089/neu.2005.22.313
– ident: e_1_2_7_13_1
  doi: 10.1016/j.jneuroim.2012.01.001
– ident: e_1_2_7_45_1
  doi: 10.1016/j.neuint.2007.05.007
– ident: e_1_2_7_35_1
  doi: 10.1016/j.nbd.2011.09.018
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Snippet Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D‐DIGE‐PMF‐MS as a...
Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2 D ‐DIGE‐ PMF ‐ MS as a...
Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2D-DIGE-PMF-MS as a...
Proteomics and systems biology have significantly contributed to biomarker discovery in the field of brain injury. This study utilized 2 D -DIGE- PMF - MS as a...
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StartPage 3693
SubjectTerms Animals
Biology
Biomarker
Biomarkers
Biomarkers - analysis
Biomarkers - chemistry
Brain
Brain Chemistry
Control equipment
Databases, Protein
Disease Models, Animal
Head Injuries, Penetrating - metabolism
Head Injuries, Penetrating - pathology
Histocytochemistry
Injuries
Kinases
Male
Penetrating ballistic-like brain injury
Proteins
Proteins - analysis
Proteome - analysis
Proteome - chemistry
Proteomics
Proteomics - methods
Rats
Rats, Sprague-Dawley
Systems biology
Systems Biology - methods
UCH-L1
Title Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury
URI https://api.istex.fr/ark:/67375/WNG-94TJR3MJ-J/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Felps.201200196
https://www.ncbi.nlm.nih.gov/pubmed/23161467
https://www.proquest.com/docview/1273266870
https://www.proquest.com/docview/1439770033
Volume 33
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