Radioimmunodetection of colorectal carcinoma using technetium‐99m‐labeled fab′ fragments of the immu‐4 anti‐carcinoembryonic antigen monoclonal antibody

• Published in: Cancer Vol. 73; no. S3; pp. 836 - 845
• Main Authors: Moffat, Frederick L., Vargas‐Cuba, Ruben D., Serafini, Aldo N., Javier Casillas, V., Morillo, Gaston, Benedetto, Pasquale, Robinson, David S., Ardalan, Bach, Manten, Howard D., Clark, Kimberley C., Garrido, Jose, Ketcham, Alfred S., Pinsky, Carl M.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.02.1994; Wiley-Liss
• Subjects: Animals; Antibodies, Monoclonal; Biological and medical sciences; Carcinoembryonic Antigen - immunology; colorectal carcinoma; Colorectal Neoplasms - diagnostic imaging; Digestion. Liver. Biliary tract. Spleen. Pancreas; human anti‐mouse antibodies; Humans; Immunoglobulin Fab Fragments; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Mice; monoclonal antibody Fab′ fragments; Prospective Studies; Radioimmunodetection; radioimmunoscintigraphy; Radionuclide investigations; Technetium

Background. Radioimmunodetection of cancer using monoclonal antibody fragments offers certain potential advantages over that with whole monoclonal antibodies, including the ability to image early (i.e., to provide images at an early time after injection of the radio‐antibody) while minimizing the in...