Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium

• Published in: Phytotherapy research Vol. 22; no. 11; pp. 1500 - 1505
• Main Authors: Seo, Ji Yeon, Lim, Soon Sung, Kim, Ju Ryoung, Lim, Ji-Sun, Ha, Young Ran, Lee, In Ae, Kim, Eun Ji, Park, Jung Han Yoon, Kim, Jong-Sang
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.11.2008; Wiley
• Subjects: Active Transport, Cell Nucleus; alantolactone; Animals; Biological and medical sciences; Cell Line, Tumor; detoxifying enzymes; Dose-Response Relationship, Drug; Enzyme Induction - drug effects; General pharmacology; Genes, Reporter; Glutathione Transferase - metabolism; Inula - chemistry; Inula helenium; Lactones - pharmacology; Medical sciences; Metabolic Detoxication, Phase II; Mice; NAD(P)H Dehydrogenase (Quinone) - metabolism; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; Nrf2; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phosphatidylinositol 3-Kinases - metabolism; PI3K; Plant Extracts - pharmacology; Plant Roots - chemistry; Response Elements; Sesquiterpenes, Eudesmane - pharmacology; Transcription, Genetic - drug effects; Transcriptional Activation; detoxifying enzymes; Enzyme; Induction; Pharmacognosy; Compositae; Medicinal plant; alantolactone; Inula helenium; PI3K; Nrf2; Dicotyledones; Angiospermae; Plant origin; Spermatophyta

Our previous study showed that a methanol extract of Inula helenium had the potential to induce detoxifying enzymes such as quinone reductase (QR) and glutathione S-transferase (GST) activity. In this study the methanol extract was further fractionated using silica gel chromatography and vacuum liqu...