Interruption of the cydB locus in Brucella abortus attenuates intracellular survival and virulence in the mouse model of infection

• Published in: Journal of bacteriology Vol. 183; no. 8; pp. 2454 - 2462
• Main Authors: Endley, S, McMurray, D, Ficht, T A
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.04.2001
• Subjects: Animals; Brucella abortus; Brucella abortus - genetics; Brucella abortus - growth & development; Brucella abortus - pathogenicity; Brucellosis - microbiology; Cattle; Cell Line; cydB gene; cytochrome bd oxidase; Cytochromes - genetics; Cytochromes - metabolism; Disease Models, Animal; DNA Transposable Elements; Electron Transport Chain Complex Proteins; Escherichia coli Proteins; Genetics and Molecular Biology; Humans; Macrophages - microbiology; Mice; Mice, Inbred BALB C; Mutagenesis; Oxidoreductases - genetics; Oxidoreductases - metabolism; Phenotype; Transformation, Bacterial; Virulence

Brucellosis is characterized by abortion in ruminants and a protracted undulant fever in humans, which often results in severe pathological manifestations. Scant information exists about the molecular mechanisms employed by Brucella abortus to combat host defenses or to persist and replicate within...